Results 181 to 190 of about 7,203,409 (405)

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus [PDF]

, 2000
Andrew P. Lucy
openalex   +1 more source

Foxtail Mosaic Virus-Induced Gene Silencing in Monocot Plants1[OPEN]

Plant Physiology, 2016
Na Liu, K. Xie, Q. Jia, Jinping Zhao, Tianyuan Chen, Huangai Li, Xiang Wei, Xianmin Diao, Yiguo Hong, Yule Liu   +9 more
semanticscholar   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

A viral suppressor of gene silencing in plants

, 1998
R. Anandalakshmi, Gail J. Pruss, Xin Ge, Rajendra Marathe, Allison C. Mallory, Trenton H. Smith, Vicki Vance   +6 more
openalex   +1 more source

Effect of 2D and 3D ECM and Biomechanical Cues on Human iPSC‐Derived Liver Progenitor Cell Differentiation

Advanced Healthcare Materials, EarlyView.
An engineered microtissue model is developed and optimized to investigate human liver development. Extracellular matrix composition and mechanical forces are tuned using high‐throughput assays. Human induced pluripotent stem cells serve as the cellular source, enabling the observation of de novo patterned differentiation.
Ishita Jain, Brock Grenci, Hyeon Ryoo, Yang Yuan, Salman R. Khetani, Gregory H. Underhill   +5 more
wiley   +1 more source

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Journal of the American Chemical Society, 2014
Jayaprakash K Nair, J. Willoughby, A. Chan, K. Charissé, Md. Rowshon Alam, Qianfan Wang, M. Hoekstra, P. Kandasamy, A. Kel'in, S. Milstein, Nate Taneja, Jonathan O’Shea, Sarfraz Shaikh, Ligang Zhang, R. J. van der Sluis, M. Jung, Akin Akinc, R. Hutabarat, S. Kuchimanchi, K. Fitzgerald, Tracy S. Zimmermann, T. V. van Berkel, M. Maier, K. G. Rajeev, M. Manoharan   +24 more
semanticscholar   +1 more source

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Advanced Healthcare Materials, EarlyView.
A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti, Thomas Scheibel   +4 more
wiley   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis

, 1998
Ortrun Mittelsten Scheid, Karin Afsar, Jerzy Paszkowski   +2 more
openalex   +1 more source