Results 201 to 210 of about 421,610 (258)

TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model. [PDF]

open access: yesPLoS One
Shen X   +7 more
europepmc   +1 more source

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. [PDF]

open access: yesNat Commun
Fakih HH   +21 more
europepmc   +1 more source

Protocol for triggering plant gene silencing by viral delivery of short RNA. [PDF]

open access: yesSTAR Protoc
García A   +4 more
europepmc   +1 more source

The silence of the genes

Current Opinion in Genetics & Development, 2000
About two years ago, it was recognized that introduction of double-stranded RNA (dsRNA) had a potent effect on gene expression, in particular on mRNA stability. Since then, this process has been found to occur in many different organisms, and to bear a strong resemblance to a previously recognized process in plants, called cosuppression.
R H, Plasterk, R F, Ketting
openaire   +2 more sources

Silencing Genes in the Heart

2016
Silencing of cardiac genes by RNA interference (RNAi) has developed into a powerful new method to treat cardiac diseases. Small interfering (si)RNAs are the inducers of RNAi, but cultured primary cardiomyocytes and heart are highly resistant to siRNA transfection.
Henry, Fechner   +3 more
openaire   +2 more sources

Gene silencing

2002
Gene silencing has evolved in a broad range of organisms probably as defense mechanisms against invasive nucleic acids. Two major strategies are utilized. Transcriptional gene silencing (TGS) acts to prevent RNA synthesis and posttranscriptional gene silencing (PTGS) acts to degrade existing RNA.
openaire   +2 more sources

Gene Silencing in Drosophila

1995
“After such a survey one could readily come to the conclusion that the basis of the phenomenon is much too complex for profitable continuation of its investigation at this time”. [W.K. Baker (1968), in a review entitled “Position-effect variegation.”]
openaire   +2 more sources

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