Results 1 to 10 of about 357,564 (302)

Beet Curly Top Iran Virus Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action [PDF]

Viruses, 2023
Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organization is
Saeideh Ebrahimi, Omid Eini, Alexandra Baßler, Arvid Hanke, Zeynep Yildirim, Michael Wassenegger, Gabi Krczal, Veli Vural Uslu   +7 more
doaj   +2 more sources

Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response [PDF]

Molecular Therapy: Nucleic Acids, 2021
The inhibition of immunosuppressive mechanisms may switch the balance between tolerance and surveillance, leading to an increase in antitumor activity. Regulatory T cells play an important role in the control of immunosuppression, exhibiting the unique ...
Andrea J. Manrique-Rincón, Luciana P. Ruas, Carolinne T. Fogagnolo, Randall J. Brenneman, Alexey Berezhnoy, Bianca Castelucci, Sílvio R. Consonni, Eli Gilboa, Marcio C. Bajgelman   +8 more
doaj   +2 more sources

C4, the Pathogenic Determinant of Tomato Leaf Curl Guangdong Virus, May Suppress Post-transcriptional Gene Silencing by Interacting With BAM1 Protein [PDF]

Frontiers in Microbiology, 2020
Tomato leaf curl Guangdong virus (ToLCGdV) is a begomovirus associated with a Tomato yellow leaf curl disease (TYLCD) epidemic in Guangdong province, China.
Zhenggang Li, Zhenggang Li, Zhenguo Du, Yafei Tang, Xiaoman She, Xiaomei Wang, Yanhua Zhu, Lin Yu, Guobing Lan, Zifu He, Zifu He   +10 more
doaj   +2 more sources

Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. [PDF]

PLoS Pathogens, 2018
Gene silencing is a natural antiviral defense mechanism in plants. For effective infection, plant viruses encode viral silencing suppressors to counter this plant antiviral response.
Asigul Ismayil, Yakupjan Haxim, Yunjing Wang, Huangai Li, Lichao Qian, Ting Han, Tianyuan Chen, Qi Jia, Alexander Yihao Liu, Songbiao Zhu, Haiteng Deng, Rena Gorovits, Yiguo Hong, Linda Hanley-Bowdoin, Yule Liu   +14 more
doaj   +2 more sources

Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

Frontiers in Plant Science, 2021
Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah, Ahmed H. El-Sappah, Ahmed H. El-Sappah, Kuan Yan, Kuan Yan, Qiulan Huang, Qiulan Huang, Qiulan Huang, Md. Monirul Islam, Quanzi Li, Quanzi Li, Yu Wang, Yu Wang, Muhammad Sarwar Khan, Xianming Zhao, Xianming Zhao, Reyazul Rouf Mir, Jia Li, Jia Li, Khaled A. El-Tarabily, Khaled A. El-Tarabily, Manzar Abbas, Manzar Abbas   +22 more
doaj   +1 more source

Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]

PLoS Genetics, 2008
Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris, Sharon Santoso, Anne-Marie Turner, Chiara Pastori, Peter G Hawkins   +4 more
doaj   +1 more source

FXN promoter silencing in the humanized mouse model of Friedreich Ataxia [PDF]

, 2015
Background - Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter.
Bidichandani, SI, Chutake, YK, Costello, WN, Hughes, TT, Lam, CC, Michalopulos, MG, Parikh, AC, Pook, MA   +7 more
core   +13 more sources

Transgene-induced gene silencing is not affected by a change in ploidy level. [PDF]

PLoS ONE, 2008
BACKGROUND: Whole genome duplication, which results in polyploidy, is a common feature of plant populations and a recurring event in the evolution of flowering plants.
Daniela Pignatta, Brian Dilkes, Tadeusz Wroblewski, Richard W Michelmore, Luca Comai   +4 more
doaj   +1 more source

Global Analysis of RNA-Dependent RNA Polymerase-Dependent Small RNAs Reveals New Substrates and Functions for These Proteins and SGS3 in Arabidopsis

Non-Coding RNA, 2021
RNA silencing pathways control eukaryotic gene expression transcriptionally or posttranscriptionally in a sequence-specific manner. In RNA silencing, the production of double-stranded RNA (dsRNA) gives rise to various classes of 20–24 nucleotide (nt ...
Xia Hua, Nathan D. Berkowitz, Matthew R. Willmann, Xiang Yu, Eric Lyons, Brian D. Gregory   +5 more
doaj   +1 more source

Transcriptional Silencing of Geminiviral Promoter-Driven Transgenes Following Homologous Virus Infection

Molecular Plant-Microbe Interactions, 2003
Promoters isolated from the Tomato leaf curl virus (TLCV) drive both constitutive and tissue-specific expression in transgenic tobacco. Following systemic TLCV infection of plants stably expressing TLCV promoter:GUS transgenes, transgene expression ...
Mark Seemanpillai, Ian Dry, John Randles, Ali Rezaian   +3 more
doaj   +1 more source