In vivo expression of MHC class I genes depends on the presence of a downstream barrier element. [PDF]
PLoS ONE, 2009 Regulation of MHC class I gene expression is critical to achieve proper immune surveillance. In this work, we identify elements downstream of the MHC class I promoter that are necessary for appropriate in vivo regulation: a novel barrier element that ...
Helit Cohen +5 more
doaj +1 more source
Factors influencing Barley Stripe Mosaic Virus-mediated gene silencing in wheat [PDF]
, 2010 Virus induced gene silencing (VIGS) is a technology that has been used primarily to target the virus genome in infected plants. However, if the virus genome carries inserts derived from the host plant, the system could be employed to target the mRNAs ...
Cakir, Cahid +3 more
core +1 more source
Biomolecular Concepts, 2014 Recent discoveries in eukaryotes have shown that autophagy-mediated degradation of DICER and ARGONAUTE (AGO), the proteins involved in post-transcriptional gene silencing (PTGS), can occur in response to viral infection and starvation.
Youngson Neil A. +2 more
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A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
Molecular Therapy: Nucleic Acids, 2014 This review discusses recent developments in the use of non-coding RNAs (ncRNAs) for the regulation of therapeutically relevant genes, with special focus on applications for the treatment of cardiovascular diseases.
Tiia Husso +2 more
doaj +1 more source
A high-resolution map of transcriptional repression
eLife, 2017 Turning genes on and off is essential for development and homeostasis, yet little is known about the sequence and causal role of chromatin state changes during the repression of active genes.
Ziwei Liang +8 more
doaj +1 more source
The post-transcriptional gene silencing pathway in Eucalyptus
Genetics and Molecular Biology, 2005 Post-transcriptional gene silencing (PTGS) is a conserved surveillance mechanism that identifies and cleaves double-stranded RNA molecules and their cellular cognate transcripts.
Flávio Tetsuo Sassaki +2 more
doaj +1 more source
AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. [PDF]
PLoS ONE, 2011 RNA-directed DNA methylation (RdDM) is a small interfering RNA (siRNA)-mediated epigenetic modification that contributes to transposon silencing in plants. RdDM requires a complex transcriptional machinery that includes specialized RNA polymerases, named
Changho Eun +8 more
doaj +1 more source
Potato virus X-induced gene silencing in leaves and tubers of potato [PDF]
, 2004 Virus induced gene silencing (VIGS) is increasingly used to generate transient loss-of-function assays and has potential as a powerful reverse-genetics tool in functional genomic programs as a more rapid alternative to stable transformation. A previously
Loake, Gary J +17 more
core +1 more source
Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica. [PDF]
PLoS Pathogens, 2006 In a previous work we described the transcriptional silencing of the amoebapore A (AP-A) gene (Ehap-a) of Entamoeba histolytica strain HM-1:IMSS. The silencing occurred following transfection with a plasmid containing a 5' upstream region (473 bp) of ...
Rivka Bracha +3 more
doaj +2 more sources
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
Nature Communications, 2019 In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
Antoine Campagne +14 more
doaj +1 more source