Results 61 to 70 of about 1,124,626 (332)

Induction and maintenance of DNA methylation in plant promoter sequences by apple latent spherical virus-induced transcriptional gene silencing

Frontiers in Microbiology, 2014
Apple latent spherical virus (ALSV) is an efficient virus-induced gene silencing vector in functional genomics analyses of a broad range of plant species.
T. Kon, N. Yoshikawa
semanticscholar   +1 more source

Mechanisms of microRNA mediated gene silencing in C. elegans [PDF]

, 2009
Mechanisms of microRNA mediated gene silencing in C. elegans Xavier Ding Dissertation abstract microRNAs (miRNAs) are a large family of small non-coding RNAs, which post-transcriptionally repress numerous genes; a type of regulation which is ...
Ding, Xavier
core   +1 more source

Overexpression of Arabidopsis thaliana ERI, the homolog of C. elegans Enhancer of RNAinterference, leads to enhanced growth

Frontiers in Plant Science, 2015
Organisms adopt a wide range of strategies to adapt to change. Gene silencing describes the ability of organisms to modulate the expression of susceptible genes at certain times at the transcriptional or the translational level.
Rhonda C Meyer, Gunnar eHönig, Ronny eBrandt, Fernando eArana-Ceballos, Cathleen eNeitsch, Gunter eReuter, Thomas eAltmann, Markus eKuhlmann   +7 more
doaj   +1 more source

Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica. [PDF]

PLoS Pathogens, 2006
In a previous work we described the transcriptional silencing of the amoebapore A (AP-A) gene (Ehap-a) of Entamoeba histolytica strain HM-1:IMSS. The silencing occurred following transfection with a plasmid containing a 5' upstream region (473 bp) of ...
Rivka Bracha, Yael Nuchamowitz, Michael Anbar, David Mirelman   +3 more
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

Nature Communications, 2019
In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z. Shahidian, Ivaylo Vassilev, Nicolas Servant, Damarys Loew, Eric Pasmant, Sophie Postel-Vinay, Michel Wassef, Raphaël Margueron   +14 more
doaj   +1 more source

RNA Silencing against Geminivirus: Complementary Action of Posttranscriptional Gene Silencing and Transcriptional Gene Silencing in Host Recovery [PDF]

Journal of Virology, 2009
ABSTRACT RNA silencing in plants is a natural defense system mechanism against invading nucleic acids such as viruses. Geminiviruses, a family of plant viruses characterized by a circular, single-stranded DNA genome, are thought to be both inducers and targets of RNA silencing.
Edgar A, Rodríguez-Negrete, Jimena, Carrillo-Tripp, Rafael F, Rivera-Bustamante   +2 more
openaire   +2 more sources

Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

Nature
Permanent epigenetic silencing using programmable editors equipped with transcriptional repressors holds great promise for the treatment of human diseases1–3.
M. A. Cappelluti, Valeria Mollica Poeta, Sara Valsoni, Piergiuseppe Quarato, S. Merlin, I. Merelli, Angelo Lombardo   +6 more
semanticscholar   +1 more source

RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration. [PDF]

, 2012
Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer.
Anja Ehrhardt, Ehrhardt, Anja, Christina Rauschhuber, Christina Rauschhuber (167226), Anja Ehrhardt (167232), Ehrhardt Anja, Rauschhuber Christina, Rauschhuber, Christina   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source