Results 61 to 70 of about 357,564 (302)

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

Nature Communications, 2019
In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z. Shahidian, Ivaylo Vassilev, Nicolas Servant, Damarys Loew, Eric Pasmant, Sophie Postel-Vinay, Michel Wassef, Raphaël Margueron   +14 more
doaj   +1 more source

Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. [PDF]

, 2016
The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal transition, metastasis and drug/immune resistance.
Bonavida, Benjamin, Garbán, Hermes, Kaufhold, Samantha   +2 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Post-transcriptional gene silencing: Basic concepts and applications

Journal of Biosciences, 2020
Post-transcriptional gene silencing (PTGS)-mediated gene silencing exploits the cellular mechanism wherein transcripts having sequence similarity to the double-stranded RNA (dsRNA) molecules present in the cell will be subjected to degradation. PTGS is closely related to natural processes such as RNA-mediated virus resistance and cross-protection in ...
Mohd Ashraf, Ashfaq, V Dinesh, Kumar, P Soma Sekhar, Reddy, C H Anil, Kumar, K Sai, Kumar, N Narasimha, Rao, M, Tarakeswari, M, Sujatha   +7 more
openaire   +2 more sources

Silencing of a plant gene by transcriptional interference [PDF]

Nucleic Acids Research, 2009
Integration of foreign DNA into eukaryotic genomes results frequently in a total or partial loss of gene function, caused by the interruption of indispensable structures of the gene itself. Using T-DNA insertions in Arabidopsis we screened for mutants with deregulated chlorophyll precursor accumulation in etiolated seedlings.
Hedtke, Boris, Grimm, Bernhard
openaire   +2 more sources

A human somatic cell culture system for modelling gene silencing by transcriptional interference

Heliyon, 2020
Transcriptional interference and transcription through regulatory elements (transcriptional read-through) are implicated in gene silencing and the establishment of DNA methylation.
Theresa Kühnel, Helena Sophie Barbara Heinz, Nadja Utz, Tanja Božić, Bernhard Horsthemke, Laura Steenpass   +5 more
doaj   +1 more source

Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing. [PDF]

PLoS Genetics, 2013
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles.
Christiane L Belele, Lyudmila Sidorenko, Maike Stam, Rechien Bader, Mario A Arteaga-Vazquez, Vicki L Chandler   +5 more
doaj   +1 more source

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]

, 2016
Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona, Ceccarelli, Simona, Clerico, Anna, Dominici, Carlo, Mannarino, Olga, Marampon, Francesco, Marchese, Cinzia, Mcdowell, Heather P, Megiorni, Francesca, Pizer, Barry, Pizzuti, Antonio, Shukla, Rajeev   +11 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops

Nature Communications, 2023
Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2) are conserved epigenetic regulators that promote transcriptional gene silencing. PRC1 and PRC2 converge on shared targets, catalyzing repressive histone modifications. Additionally, a subset of PRC1/PRC2
Daniel Bsteh, Hagar F. Moussa, Georg Michlits, Ramesh Yelagandula, Jingkui Wang, Ulrich Elling, Oliver Bell   +6 more
doaj   +1 more source