Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq [PDF]
Nature Communications, 2017 There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with the nucleoplasmic protein Sfpq in an RNA-dependent fashion.
Silvia Bottini +11 more
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Beet Curly Top Iran Virus Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action [PDF]
Viruses, 2023 Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organization is
Saeideh Ebrahimi +7 more
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MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases [PDF]
Molecular Therapy: Nucleic AcidsMicroRNAs (miRNAs) are small, non-coding RNAs that influence various cellular activities through post-transcriptional gene silencing. Recent research has shown that miRNA modifications, including N6-methyladenosine (m6A), 5-methylcytidine (m5C), 2′-O ...
Amin Alaei, Pavan Kumar Kakumani
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Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. [PDF]
PLoS Pathogens, 2018 Gene silencing is a natural antiviral defense mechanism in plants. For effective infection, plant viruses encode viral silencing suppressors to counter this plant antiviral response.
Asigul Ismayil +14 more
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C4, the Pathogenic Determinant of Tomato Leaf Curl Guangdong Virus, May Suppress Post-transcriptional Gene Silencing by Interacting With BAM1 Protein [PDF]
Frontiers in Microbiology, 2020 Tomato leaf curl Guangdong virus (ToLCGdV) is a begomovirus associated with a Tomato yellow leaf curl disease (TYLCD) epidemic in Guangdong province, China.
Zhenggang Li +10 more
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Gene Inactivation in Transgenic Plants—A Unique Model for Studying Epigenetic Regulation of Gene Expression [PDF]
PlantsThe phenomenon of transgene silencing was first observed shortly after the generation of the initial transgenic plants. The vast body of experimental data accumulated since then constitutes an invaluable resource for dissecting the mechanisms of ...
Tatyana V. Marenkova +3 more
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Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development
Frontiers in Plant Science, 2021 Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah +22 more
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Transgene-induced gene silencing is not affected by a change in ploidy level. [PDF]
PLoS ONE, 2008 BACKGROUND: Whole genome duplication, which results in polyploidy, is a common feature of plant populations and a recurring event in the evolution of flowering plants.
Daniela Pignatta +4 more
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Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]
PLoS Genetics, 2008 Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris +4 more
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Post-transcriptional regulation of several biological processes involved in latex production in Hevea brasiliensis [PDF]
PeerJ, 2020 Background Small RNAs modulate plant gene expression at both the transcriptional and post-transcriptional level, mostly through the induction of either targeted DNA methylation or transcript cleavage, respectively.
Julie Leclercq +13 more
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