Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase [PDF]
PLoS Pathogens, 2018 Gene silencing is a natural antiviral defense mechanism in plants. For effective infection, plant viruses encode viral silencing suppressors to counter this plant antiviral response.
Linda Hanley-Bowdoin +2 more
exaly +4 more sources
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus. [PDF]
World J Virol, 2015 While human immunodeficiency virus 1 (HIV-1) infection is controlled through continuous, life-long use of a combination of drugs targeting different steps of the virus cycle, HIV-1 is never completely eradicated from the body. Despite decades of research
Méndez C, Ahlenstiel CL, Kelleher AD.
europepmc +6 more sources
Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. [PDF]
Nat Commun, 2017 There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with the nucleoplasmic protein Sfpq in an RNA-dependent fashion.
Bottini S +11 more
europepmc +7 more sources
Exogenous miRNAs induce post-transcriptional gene silencing in plants. [PDF]
Nat Plants, 2021 Plants seem to take up exogenous RNA that was artificially designed to target specific genes, followed by activation of the RNA interference (RNAi) machinery.
Betti F +11 more
europepmc +6 more sources
MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases. [PDF]
Mol Ther Nucleic AcidsMicroRNAs (miRNAs) are small, non-coding RNAs that influence various cellular activities through post-transcriptional gene silencing. Recent research has shown that miRNA modifications, including N6-methyladenosine (m6A), 5-methylcytidine (m5C), 2′-O ...
Alaei A, Kakumani PK.
europepmc +3 more sources
Post-transcriptional gene silencing in plants: a double-edged sword [PDF]
Science China Life Sciences, 2015 In plants, post-transcriptional gene silencing (PTGS) protects the genome from foreign genes and restricts the expression of certain endogenous genes for proper development.
Hongwei Guo, Xinyan Zhang
exaly +4 more sources
C4, the Pathogenic Determinant of Tomato Leaf Curl Guangdong Virus, May Suppress Post-transcriptional Gene Silencing by Interacting With BAM1 Protein. [PDF]
Front Microbiol, 2020 Tomato leaf curl Guangdong virus (ToLCGdV) is a begomovirus associated with a Tomato yellow leaf curl disease (TYLCD) epidemic in Guangdong province, China.
Li Z +8 more
europepmc +2 more sources
Beet Curly Top Iran Virus Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action. [PDF]
Viruses, 2023 Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organization is
Ebrahimi S +7 more
europepmc +2 more sources
Efficient CRISPR-Mediated Post-Transcriptional Gene Silencing in a Hyperthermophilic Archaeon Using Multiplexed crRNA Expression. [PDF]
G3 (Bethesda), 2016 CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-mediated RNA degradation is catalyzed by a type III system in the hyperthermophilic archaeon Sulfolobus solfataricus. Earlier work demonstrated that the system can be engineered to target
Zebec Z, Zink IA, Kerou M, Schleper C.
europepmc +2 more sources
The divergent V2 protein encoded by parsley yellow leaf curl virus is a suppressor of transcriptional and post-transcriptional gene silencing and a potential symptom determinant. [PDF]
BMC Plant BiolThe Geminiviridae family encompasses over 500 species of economically important plant viruses. A new geminivirus species named parsley yellow leaf curl virus (PYLCV) was first identified in 2020 in Southeastern Iran.
Zeitooni H +3 more
europepmc +2 more sources