Results 11 to 20 of about 168,099 (250)
Variables and Strategies in Development of Therapeutic Post-Transcriptional Gene Silencing Agents [PDF]
Journal of Ophthalmology, 2011 Post-transcriptional gene silencing (PTGS) agents such as ribozymes, RNAi and antisense have substantial potential for gene therapy of human retinal degenerations.
Jack M. Sullivan +5 more
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Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development
Frontiers in Plant Science, 2021 Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah +22 more
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Characteristics of post‐transcriptional gene silencing [PDF]
The EMBO Reports, 2001 A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles ...
A. Chicas, MACINO, Giuseppe
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Transgene-induced gene silencing is not affected by a change in ploidy level. [PDF]
PLoS ONE, 2008 BACKGROUND: Whole genome duplication, which results in polyploidy, is a common feature of plant populations and a recurring event in the evolution of flowering plants.
Daniela Pignatta +4 more
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Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]
PLoS Genetics, 2008 Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris +4 more
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Virus‐Induced Gene Silencing, a Post Transcriptional Gene Silencing Method [PDF]
International Journal of Plant Genomics, 2009 Virus‐induced gene silencing (VIGS) is one of the reverse genetics tools for analysis of gene function that uses viral vectors carrying a target gene fragment to produce dsRNA which trigger RNA‐mediated gene silencing. There are a number of viruses which have been modified to silence the gene of interest effectively with a sequence‐specific manner ...
Unver, Turgay, Budak, Hikmet
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Enhancement of post-transcriptional gene silencing by grafting [PDF]
Plant Signaling & Behavior, 2008 We showed previously that grafting transmitted silencing occurred when transgenic ACC oxidase 1 (ACO1) overexpressing tomato plants that also produced siRNAs were grafted onto transgenic stocks that already showed strong silencing. The presence of siRNAs in these overexpressing scions may indicate that silencing, though inefficient, may already occur ...
Yuanhuai, Han, Donald, Grierson
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Post-transcriptional regulation of several biological processes involved in latex production in Hevea brasiliensis [PDF]
PeerJ, 2020 Background Small RNAs modulate plant gene expression at both the transcriptional and post-transcriptional level, mostly through the induction of either targeted DNA methylation or transcript cleavage, respectively.
Julie Leclercq +13 more
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Plants, 2022 Flavonoid biosynthesis requires the activities of several enzymes, which form weakly-bound, ordered protein complexes termed metabolons. To decipher flux regulation in the flavonoid biosynthetic pathway of chrysanthemum (Chrysanthemum morifolium Ramat ...
Sun-Hyung Lim +5 more
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Post-transcriptional gene silencing in a dynamic RNP world
Biological Chemistry, 2023 Abstract MicroRNA (miRNA)-guided gene silencing is a key regulatory process in various organisms and linked to many human diseases. MiRNAs are processed from precursor molecules and associate with Argonaute proteins to repress the expression of complementary target mRNAs.
Simone Larivera +2 more
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