Results 31 to 40 of about 168,099 (250)

The convergence of autophagy, small RNA and the stress response – implications for transgenerational epigenetic inheritance in plants

Biomolecular Concepts, 2014
Recent discoveries in eukaryotes have shown that autophagy-mediated degradation of DICER and ARGONAUTE (AGO), the proteins involved in post-transcriptional gene silencing (PTGS), can occur in response to viral infection and starvation.
Youngson Neil A., Lin Pin-Chun, Lin Shih-Shun   +2 more
doaj   +1 more source

RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex.

PLoS ONE, 2013
BackgroundBeyond their role in post-transcriptional gene silencing, Dicer and Argonaute, two components of the RNA interference (RNAi) machinery, were shown to be involved in epigenetic regulation of centromeric heterochromatin and transcriptional gene ...
Filippo M Cernilogar, A Maxwell Burroughs, Chiara Lanzuolo, Achim Breiling, Axel Imhof, Valerio Orlando   +5 more
doaj   +1 more source

Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2

Frontiers in Microbiology, 2021
Geminiviruses are plant DNA viruses that infect a wide range of plant species and cause significant losses to economically important food and fiber crops.
Karuppannan Veluthambi, Sukumaran Sunitha   +1 more
doaj   +1 more source

Overexpression of Arabidopsis thaliana ERI, the homolog of C. elegans Enhancer of RNAinterference, leads to enhanced growth

Frontiers in Plant Science, 2015
Organisms adopt a wide range of strategies to adapt to change. Gene silencing describes the ability of organisms to modulate the expression of susceptible genes at certain times at the transcriptional or the translational level.
Rhonda C Meyer, Gunnar eHönig, Ronny eBrandt, Fernando eArana-Ceballos, Cathleen eNeitsch, Gunter eReuter, Thomas eAltmann, Markus eKuhlmann   +7 more
doaj   +1 more source

Modulation of miRISC-Mediated Gene Silencing in Eukaryotes

Frontiers in Molecular Biosciences, 2022
Gene expression is regulated at multiple levels in eukaryotic cells. Regulation at the post-transcriptional level is modulated by various trans-acting factors that bind to specific sequences in the messenger RNA (mRNA).
Courtney F. Jungers, Sergej Djuranovic
doaj   +1 more source

Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury. [PDF]

PLoS ONE, 2012
Injury response in the peripheral nervous system (PNS) is characterized by rapid alterations in the genetic program of Schwann cells. However, the epigenetic mechanisms modulating these changes remain elusive.
Tadepalli Adilakshmi, Ida Sudol, Nikos Tapinos   +2 more
doaj   +1 more source

The Diversity of Plant Small RNAs Silencing Mechanisms

CHIMIA, 2019
Small RNAs gene regulation was first discovered about 20 years ago. It represents a conserve gene regulation mechanism across eukaryotes and is associated to key regulatory processes.
Jens A. Schröder, Pauline E. Jullien
doaj   +1 more source

Antiviral innate immune response of RNA interference

Journal of Infection in Developing Countries, 2014
RNA interference (RNAi) is an ancient, natural process conserved among species from different kingdoms. RNAi is a transcriptional and post-transcriptional gene silencing mechanism in which, double-stranded RNA or hairpin RNA is cleaved by an RNase III ...
Abubaker Sidahmed, Shaza Abdalla, Salahedin Mahmud, Bruce Wilkie   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source