Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]
, 2015 Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane +2 more
core +2 more sources
Post-transcriptional gene silencing in plants: a double-edged sword [PDF]
Science China Life Sciences, 2015 في النباتات، يحمي إسكات الجينات بعد النسخ (PTGS) الجينوم من الجينات الغريبة ويقيد التعبير عن بعض الجينات الداخلية من أجل النمو السليم. هنا، نستعرض التقدم الأخير حول كيفية تجنب PTGS غير المرغوب فيه في النباتات. كخطوة من خطوات صنع القرار في اختبار PTGS، يتم فرز النصوص الشاذة من معظم جينات الترميز الداخلية بدقة إلى مسارات اضمحلال الحمض النووي الريبي ثنائي
Xinyan Zhang +3 more
openaire +2 more sources
Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
, 2015 Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Huitema, Edgar +3 more
core +3 more sources
RNA-DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing [PDF]
The Plant Cell, 1999 Post-transcriptional gene silencing (PTGS) is a homology-dependent process that reduces cytoplasmic RNA levels. In several experimental systems, there is also an association of PTGS with methylation of DNA. To investigate this association, we used plants carrying a transgene encoding the green fluorescent protein (GFP). Gene silencing was induced using
L, Jones +5 more
openaire +2 more sources
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]
, 2016 Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona +11 more
core +1 more source
Antiviral innate immune response of RNA interference
Journal of Infection in Developing Countries, 2014 RNA interference (RNAi) is an ancient, natural process conserved among species from different kingdoms. RNAi is a transcriptional and post-transcriptional gene silencing mechanism in which, double-stranded RNA or hairpin RNA is cleaved by an RNase III ...
Abubaker Sidahmed +3 more
doaj +1 more source
Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]
, 2016 Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi +56 more
core +1 more source
The Diversity of Plant Small RNAs Silencing Mechanisms
CHIMIA, 2019 Small RNAs gene regulation was first discovered about 20 years ago. It represents a conserve gene regulation mechanism across eukaryotes and is associated to key regulatory processes.
Jens A. Schröder, Pauline E. Jullien
doaj +1 more source
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]
, 2006 Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core +1 more source
Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
core +2 more sources