Results 51 to 60 of about 7,617,750 (308)
Frontiers in Plant Science, 2015 Organisms adopt a wide range of strategies to adapt to change. Gene silencing describes the ability of organisms to modulate the expression of susceptible genes at certain times at the transcriptional or the translational level.
Rhonda C Meyer +7 more
doaj +1 more source
Modulation of miRISC-Mediated Gene Silencing in Eukaryotes
Frontiers in Molecular Biosciences, 2022 Gene expression is regulated at multiple levels in eukaryotic cells. Regulation at the post-transcriptional level is modulated by various trans-acting factors that bind to specific sequences in the messenger RNA (mRNA).
Courtney F. Jungers, Sergej Djuranovic
doaj +1 more source
Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury. [PDF]
PLoS ONE, 2012 Injury response in the peripheral nervous system (PNS) is characterized by rapid alterations in the genetic program of Schwann cells. However, the epigenetic mechanisms modulating these changes remain elusive.
Tadepalli Adilakshmi +2 more
doaj +1 more source
Nucleic Acids Research, 2015 Although post-transcriptional gene silencing (PTGS) has been studied for more than a decade, there is still a gap in our understanding of how de novo silencing is initiated against genetic elements that are not supposed to produce double-stranded (ds)RNA.
Jean-Sébastien Parent +6 more
semanticscholar +1 more source
Antiviral innate immune response of RNA interference
Journal of Infection in Developing Countries, 2014 RNA interference (RNAi) is an ancient, natural process conserved among species from different kingdoms. RNAi is a transcriptional and post-transcriptional gene silencing mechanism in which, double-stranded RNA or hairpin RNA is cleaved by an RNase III ...
Abubaker Sidahmed +3 more
doaj +1 more source
Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]
, 2010 A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Premkumar P +7 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Diversity of Plant Small RNAs Silencing Mechanisms
CHIMIA, 2019 Small RNAs gene regulation was first discovered about 20 years ago. It represents a conserve gene regulation mechanism across eukaryotes and is associated to key regulatory processes.
Jens A. Schröder, Pauline E. Jullien
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum [PDF]
, 2013 Clonally variant protein expression in the malaria parasite Plasmodium falciparum generates phenotypic variability and allows isogenic populations to adapt to environmental changes encountered during blood stage infection.
Nicolas M B Brancucci +13 more
core +1 more source