Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei:evidence for genome-wide conservation of life-cycle stage-specific regulatory elements [PDF]
, 2006 Trypanosomes represent an excellent model for the post-transcriptional regulation of gene expression because their genome is organized into polycistronic transcription units.
Katelyn Fenn +10 more
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Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]
, 2009 In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
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mBioUnique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and changes in gene expression are ...
Rudo Kieft +5 more
doaj +1 more source
Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. [PDF]
, 2012 Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast.
Ragna Sack +37 more
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EMBO ReportsTransposable elements (TEs) are repressed in plants through transcriptional gene silencing (TGS), maintained epigenetic silencing marks such as DNA methylation.
Marieke Trasser +6 more
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Activation of systemic acquired silencing by localised introduction of DNA [PDF]
, 1999 Background: In plants, post-transcriptional gene silencing results in RNA degradation after transcription. Among tobacco transformants carrying a nitrate reductase (Nia) construct under the control of the cauliflower mosaic virus 35S promoter (35S–Nia2),
Sandrine Balzergue +3 more
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Defense pathways in Arabidopsis restricting compatible tobamoviruses during infection [PDF]
, 2014 Virus infected plants often develop strong disease symptoms including leaf deformation, chlorosis, necrosis and growth inhibition. In agriculture systems virus infection can lead to severe yield losses and a better understanding of plant defenses against
Kørner, Camilla Julie
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Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]
, 2007 Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea +7 more
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Biogenesis, Function and Applications of Virus-Derived Small RNAs in Plants
Frontiers in Microbiology, 2015 RNA silencing, an evolutionarily conserved and sequence-specific gene-inactivation system, has a pivotal role in antiviral defense in most eukaryotic organisms.
Chao eZhang +4 more
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Dicer Finds a New Partner in Transcriptional Gene Silencing [PDF]
Molecular Cell, 2007 In a recent study in Molecular Cell, Colmenares et al. (2007) showed that fission yeast Dicer is physically and functionally associated with RNA-dependent RNA polymerase complex (RDRC), revealing a concerted mechanism in transcriptional gene silencing.
openaire +2 more sources