Results 91 to 100 of about 1,124,626 (332)

Defense pathways in Arabidopsis restricting compatible tobamoviruses during infection [PDF]

, 2014
Virus infected plants often develop strong disease symptoms including leaf deformation, chlorosis, necrosis and growth inhibition. In agriculture systems virus infection can lead to severe yield losses and a better understanding of plant defenses against
Kørner, Camilla Julie
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. [PDF]

, 2012
Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast.
Ragna Sack, Tsai-Pflugfelder Monika, Gasser, Susan M, Ferreira, Helder C., Kueng Stephanie, Oppikofer, Mariano, Roberts, Emma, Sack, Ragna, Roloff, Tim-Christoph, Gasser, Susan M., Mariano Oppikofer, Chinyen Tsai (163222), Tim-Christoph Roloff (163227), Emma Roberts, Tsai-Pflugfelder, Monika, Helder C. Ferreira (163213), Tsai Chinyen, Ferreira Helder C., Helder C Ferreira, Oppikofer Mariano, Mariano Oppikofer (163208), Kueng, Stephanie, Roloff Tim-Christoph, Ferreira, Helder C, Roberts Emma, Tsai, Chinyen, Stephanie Kueng, Monika Tsai-Pflugfelder, Stephanie Kueng (163200), Susan M Gasser, Ragna Sack (163231), Emma Roberts (163217), Susan M. Gasser (163235), Tim-Christoph Roloff, Monika Tsai-Pflugfelder (163204), Gasser Susan M., Sack Ragna, Chinyen Tsai   +37 more
core   +1 more source

Preventing transcriptional gene silencing by active DNA demethylation [PDF]

FEBS Letters, 2005
DNA methylation is important for stable transcriptional gene silencing. DNA methyltransferases for de novo as well as maintenance methylation have been well characterized. However, enzymes responsible for active DNA demethylation have been elusive and several reported mechanisms of active demethylation have been controversial. There has been a critical
Kapoor, Avnish, Agius, Fernanda, Zhu, Jian-Kang   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Gene Silencing: The Mechanism to Down Regulate the Target Gene

International Journal of Bio-Resource and Stress Management, 2018
Gene silencing is one of the most efficient and promising functional genomics tools which down regulates the expression of a gene in a very precise manner and has significant impact on crop improvement.
Shreya, Ajeet Kumar Pandey, H. R. Bhandari   +2 more
doaj  

The Diversity of Plant Small RNAs Silencing Mechanisms

CHIMIA, 2019
Small RNAs gene regulation was first discovered about 20 years ago. It represents a conserve gene regulation mechanism across eukaryotes and is associated to key regulatory processes.
Jens A. Schröder, Pauline E. Jullien
doaj   +1 more source

Virus and Viroid-Derived Small RNAs as Modulators of Host Gene Expression: Molecular Insights Into Pathogenesis

Frontiers in Microbiology, 2021
Virus-derived siRNAs (vsiRNAs) generated by the host RNA silencing mechanism are effectors of plant’s defense response and act by targeting the viral RNA and DNA in post-transcriptional gene silencing (PTGS) and transcriptional gene silencing (TGS ...
S. V. Ramesh, Sneha Yogindran, Prabu Gnanasekaran, Supriya Chakraborty, Stephan Winter, Hanu R. Pappu   +5 more
doaj   +1 more source

Transcriptional control and gene silencing inPlasmodium falciparum

Cellular Microbiology, 2008
Infection with the apicomplexan parasite Plasmodium falciparum is associated with a high burden of morbidity and mortality across the developing world, yet the mechanisms of transcriptional control in this organism are poorly understood. While P. falciparum possesses many of the characteristics common to eukaryotic transcription, including much of the ...
Coleman, Bradley I., Duraisingh, Manoj T.   +1 more
openaire   +2 more sources

Efficient cloning system for construction of gene silencing vectors in Aspergillus niger

, 2008
An approach based on Gateway recombination technology to efficiently construct silencing vectors was developed for use in the biotechnologically important fungus Aspergillus niger. The transcription activator of xylanolytic and cellulolytic genes XlnR of
Oliveira, J.M., Graaff, L.H., de, Veen, D., van der, Qin Ling   +3 more
core   +1 more source