Results 111 to 120 of about 1,124,626 (332)

Rhodopsin targeted transcriptional silencing by DNA-binding

eLife, 2016
Transcription factors (TFs) operate by the combined activity of their DNA-binding domains (DBDs) and effector domains (EDs) enabling the coordination of gene expression on a genomic scale.
Salvatore Botta, Elena Marrocco, Nicola de Prisco, Fabiola Curion, Mario Renda, Martina Sofia, Mariangela Lupo, Annamaria Carissimo, Maria Laura Bacci, Carlo Gesualdo, Settimio Rossi, Francesca Simonelli, Enrico Maria Surace   +12 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters

, 2010
Antigene RNAs (agRNAs) are small RNA duplexes that target non-coding transcripts rather than mRNA and specifically suppress or activate gene expression in a sequence-dependent manner.
Charisse, Klaus, Yu, Dongbo, Montaillier, Christophe, Potier, Pierre, Corey, David R., Manoharan, Muthiah, Watts, Jonathan K.   +6 more
core   +1 more source

Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]

, 2012
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski, Martina Rieder, Caroline C. Friedel (7812728), Marcinowski, Lisa, Lars Dölken, de Graaf, Miranda, Thomas Bonfert, Caroline C. Friedel (29226), Lars Dölken (138985), Györy, Ildiko, Caroline C Friedel, Philip Rosenstiel (68103), Jens B Bosse, Ruzsics, Zsolt, Ralf Zimmer, Bosse, Jens B., Lukas Windhager, Rosenstiel, Philip, Zsolt Ruzsics (75383), Jens B. Bosse (7812725), Zimmer, Ralf, Thomas Bonfert (138970), Rieder, Martina, Lisa Marcinowski (138962), Jens B. Bosse (138966), Friedel, Caroline C., Ildiko Györy (138972), Michael Lidschreiber, Ildiko Györy, Bernd Rädle (138968), Zsolt Ruzsics, Ralf Zimmer (21157), Windhager, Lukas, Miranda de Graaf, Philip Rosenstiel, Michael Lidschreiber (138963), Dölken, Lars, Olivia Prazeres da Costa, Prazeres da Costa, Olivia, Olivia Prazeres da Costa (138979), Bernd Rädle, Lukas Windhager (138964), Lidschreiber, Michael, Miranda de Graaf (138976), Bonfert, Thomas, Rädle, Bernd, Martina Rieder (138965)   +46 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

Retrovirology, 2018
Background Current antiretroviral therapy is effective in controlling HIV-1 infection. However, cessation of therapy is associated with rapid return of viremia from the viral reservoir.
Catalina Méndez, Scott Ledger, Kathy Petoumenos, Chantelle Ahlenstiel, Anthony D. Kelleher   +4 more
doaj   +1 more source

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells

Nature Structural &Molecular Biology, 2012
We show that convergent transcription induces transcriptional gene silencing (TGS) in trans for both fission yeast and mammalian cells. This method has advantages over existing strategies to induce gene silencing.
M. Gullerová, N. Proudfoot
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source