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Transcriptional gene silencing in humans. [PDF]
Nucleic Acids Res, 2016 It has been over a decade since the first observation that small non-coding RNAs can functionally modulate epigenetic states in human cells to achieve functional transcriptional gene silencing (TGS). TGS is mechanistically distinct from the RNA interference (RNAi) gene-silencing pathway.
Weinberg MS, Morris KV.
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Characteristics of post‐transcriptional gene silencing [PDF]
The EMBO Reports, 2001 A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles ...
A. Chicas, MACINO, Giuseppe
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New Partners for HP1 in Transcriptional Gene Silencing [PDF]
Molecular Cell, 2011 A new study in this issue of Molecular Cell (Yamane et al., 2010) demonstrates how chromatin assembly proteins HIRA/Asf1 help enforce transcriptional gene silencing in heterochromatin by bridging interactions between HP1 and histone deacetylase complexes.
Kaufman, Paul D., Paul D. Kaufman
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Therapeutic potential of siRNA-mediated transcriptional gene silencing
BioTechniques, 2006 RNA interference (RNAi) and specifically the use of small interfering RNAs (siRNAs) represents a potentially new paradigm in gene knockout technology. Clearly siRNAs can be used to knockdown the expression of a targeted transcript in what has been termed
Kevin V. Morris
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Transcriptional gene silencing mutants
Plant Molecular Biology, 2000 Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans.
Mittelsten Scheid, O., Paszkowski, Jerzy
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Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections
Biology, 2012 Gene silencing via non-coding RNA, such as siRNA and miRNA, can occur at the transcriptional, post-transcriptional, and translational stages of expression.
Fatah Kashanchi +7 more
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Dicer Finds a New Partner in Transcriptional Gene Silencing [PDF]
Molecular Cell, 2007 In a recent study in Molecular Cell, Colmenares et al. (2007) showed that fission yeast Dicer is physically and functionally associated with RNA-dependent RNA polymerase complex (RDRC), revealing a concerted mechanism in transcriptional gene silencing.
Ramin Shiekhattar, Shiekhattar, Ramin
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Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus. [PDF]
World J Virol, 2015 While human immunodeficiency virus 1 (HIV-1) infection is controlled through continuous, life-long use of a combination of drugs targeting different steps of the virus cycle, HIV-1 is never completely eradicated from the body. Despite decades of research there is still no effective vaccine to prevent HIV-1 infection.
Méndez C, Ahlenstiel CL, Kelleher AD.
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RNA interference is ineffective as a routine method for gene silencing in chick embryos as monitored by fgf8 silencing. [PDF]
, 2013 The in vivo accessibility of the chick embryo makes it a favoured model system for experimental developmental biology. Although the range of available techniques now extends to miss-expression of genes through in ovo electroporation, it remains difficult
Bueno i Torrens, David, 1965- +1 more
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Investigation of RNA-induced gene silencing in the fission yeast Schizosaccharomyces pombe [PDF]
, 2007 PhDRNA interference (RNAi) is a gene regulating system to which can silence genes at both transcriptional and post-transcriptional levels. In this thesis, a ura4-based RNAi selective assay was developed in the fission yeast Schizosaccharomyces pombe ...
Wang, Huan
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