Results 11 to 20 of about 1,124,626 (332)
Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus. [PDF]
Sci Rep, 2015 Although histone H3K9 methylation has been intensively studied in animals and a model plant Arabidopsis thaliana, little is known about the evolution of the histone methyltransferase and its roles in plant biotic stress response.
Sun YW +5 more
europepmc +2 more sources
Characteristics of post‐transcriptional gene silencing [PDF]
EMBO reports, 2001 A number of gene silencing phenomena that inactivate genes at the post‐transcriptional level have been identified. Due to its potential for studying gene function, post‐transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles ...
A. Chicas, MACINO, Giuseppe
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Cell Research, 2014 The SU(VAR)3-9-like histone methyltransferases usually catalyze repressive histone H3K9 methylation and are involved in transcriptional gene silencing in eukaryotic organisms.
Yong-Feng Han +2 more
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Therapeutic potential of siRNA-mediated transcriptional gene silencing
BioTechniques, 2006 RNA interference (RNAi) and specifically the use of small interfering RNAs (siRNAs) represents a potentially new paradigm in gene knockout technology. Clearly siRNAs can be used to knockdown the expression of a targeted transcript in what has been termed
Kevin V. Morris
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Antisense transcription licenses nascent transcripts to mediate transcriptional gene silencing. [PDF]
Genes Dev, 2016 In eukaryotes, antisense transcription can regulate sense transcription by induction of epigenetic modifications. We showed previously that antisense transcription triggers Dicer-independent siRNA (disiRNA) production and disiRNA locus DNA methylation (DLDM) in Neurospora crassa.
Dang Y, Cheng J, Sun X, Zhou Z, Liu Y.
europepmc +4 more sources
AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. [PDF]
PLoS ONE, 2011 RNA-directed DNA methylation (RdDM) is a small interfering RNA (siRNA)-mediated epigenetic modification that contributes to transposon silencing in plants. RdDM requires a complex transcriptional machinery that includes specialized RNA polymerases, named
Changho Eun +8 more
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New Partners for HP1 in Transcriptional Gene Silencing [PDF]
Molecular Cell, 2011 A new study in this issue of Molecular Cell (Yamane et al., 2010) demonstrates how chromatin assembly proteins HIRA/Asf1 help enforce transcriptional gene silencing in heterochromatin by bridging interactions between HP1 and histone deacetylase complexes.
Kaufman, Paul D., Paul D. Kaufman
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Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury. [PDF]
PLoS ONE, 2012 Injury response in the peripheral nervous system (PNS) is characterized by rapid alterations in the genetic program of Schwann cells. However, the epigenetic mechanisms modulating these changes remain elusive.
Tadepalli Adilakshmi +2 more
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Journal of Biological Chemistry, 2011 Background: The mechanism(s) of G3-based TGS in E. histolytica is largely unknown. Results: 5′-polyphosphate antisense sRNAs are identified; mechanistic insights linking these sRNAs with TGS are provided by IFA, FISH, IP, and ChIP assays. Conclusion: TGS
Hanbang Zhang, Vy Tran, Upinder Singh
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