Results 211 to 220 of about 7,554,622 (397)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Enhanced microRNA accumulation and gene silencing efficiency through optimized precursor base pairing. [PDF]

Plant J
Llorens-Gámez JJ, García-Cano PJ, Rico-Rodrigo S, Duyos-Casanova L, Toledano-Franco S, Carbonell A.   +5 more
europepmc   +1 more source

The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis [PDF]

, 2006
Yu Wang, Jun Liu, Ran Xia, Junguo Wang, Jie Shen, Rui Cao, Xuhui Hong, Jian‐Kang Zhu, Zhizhong Gong   +8 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Exploitation of Biocomputational Approaches for siRNA-Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer. [PDF]

Cancer Rep (Hoboken)
Masum MHU, Parvin R, Heema HP, Akter A, Ferdous J.   +4 more
europepmc   +1 more source

Supplementary Material for: The EFEMP1 Gene: A Frequent Target for Epigenetic Silencing in Multiple Human Pituitary Adenoma Subtypes

, 2017
Cathy Duong, Kiren Yacqub‐Usman, Richard D. Emes, Richard N. Clayton, William E. Farrell   +4 more
openalex   +1 more source

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

Cell, 2005
R. Gregory, T. Chendrimada, Neil Cooch, R. Shiekhattar   +3 more
semanticscholar   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases. [PDF]

Mol Ther Nucleic Acids
Alaei A, Kakumani PK.
europepmc   +1 more source

Silencing Genes Encoding Omega-3 Fatty Acid Desaturase Alters Seed Size and Accumulation of Bean pod mottle virus in Soybean

, 2010
Ajay Singh, Daqi Fu, Mohamed El‐Habbak, Duroy A. Navarre, Said A. Ghabrial, Aardra Kachroo   +5 more
openalex   +2 more sources