Results 81 to 90 of about 7,554,622 (397)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Green Fluorescent Protein (GFP) in Vector Systems Played Sense Role of Epigenetic in Plants [PDF]
, 2008 The green fluorescent protein (GFP) of jellyfish (_Aequorea victoria_) has significant advantages over other reporter genes, because expression can be detected in living cells without any substrates.
Hany A. El-Shemy +2 more
core +1 more source
Molecular Plant-Microbe Interactions, 2007 Tomato bushy stunt virus (TBSV) coat protein (CP) replacement vectors have been used previously to silence transgenes (e.g., the green fluorescent protein gene) but have not been effective for silencing endogenous plant genes.
Daniela Pignatta +4 more
doaj +1 more source
Plant gene silencing regularized [PDF]
Proceedings of the National Academy of Sciences, 1998 Two surprising and potentially useful phenomena of transgenic plants originated from two distinct lines of research but may converge in underlying mechanism or mechanisms (1–3). Plant transformation technology, the staple of the crop biotechnology industry, overcomes the species barrier and allows introduction into plants of genes from other plant ...
openaire +2 more sources
Highly Specific Gene Silencing by Artificial MicroRNAs in Arabidopsis[W][OA]
The Plant Cell Online, 2006 Plant microRNAs (miRNAs) affect only a small number of targets with high sequence complementarity, while animal miRNAs usually have hundreds of targets with limited complementarity.
R. Schwab +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Regulating repression : roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states [PDF]
, 2012 The Gasser laboratory is supported by the Novartis Research Foundation and the EU training network Nucleosome 4D. SK was supported by an EMBO long-term fellowship, a Schrodinger fellowship from the FWF, and the Swiss SystemsX.ch initiative/C-CINA; HCF by
Ferreira, Helder C. +8 more
core +4 more sources
Biologia Plantarum, 2019 Virus-induced gene silencing (VIGS) is a particularly useful tool for functional genomics. In the present study, we attempted to utilize this technology to infer the function of genes from Viola philippica using a tobacco rattle virus (TRV) construct ...
Q.X. Li +5 more
doaj +1 more source
The Paf1 complex represses small RNA-mediated epigenetic gene silencing
Nature, 2015 RNA interference (RNAi) refers to the ability of exogenously introduced double-stranded RNA to silence expression of homologous sequences. Silencing is initiated when the enzyme Dicer processes the double-stranded RNA into small interfering RNAs (siRNAs).
Katarzyna Kowalik +5 more
semanticscholar +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source