Results 91 to 100 of about 454,191 (307)

Posttranscriptional gene silencing in nuclei [PDF]

Proceedings of the National Academy of Sciences, 2010
In plants, small interfering RNAs (siRNAs) with sequence homology to transcribed regions of genes can guide the sequence-specific degradation of corresponding mRNAs, leading to posttranscriptional gene silencing (PTGS). The current consensus is that siRNA-mediated PTGS occurs primarily in the cytoplasm where target mRNAs are ...
Paul, Hoffer, Sergey, Ivashuta, Olga, Pontes, Alexa, Vitins, Craig, Pikaard, Andrew, Mroczka, Nicholas, Wagner, Toni, Voelker   +7 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Using interpretable machine learning to understand gene silencing dynamics during X-chromosome inactivation [PDF]

, 2020
To equalize gene dosage between sexes, the long non-coding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals - a process known as X chromosome inactivation (XCI).
Barros de Andrade e Sousa, Lisa, Barros de Andrade e Sousa, L.   +1 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Gene silencing: Fleshing out the bones [PDF]

, 2001
Genetic studies are revealing the pathway for RNA-mediated gene silencing. Short RNA molecules are the key, giving sequence specificity for RNA degradation and mediating communication within and between cells; these short RNAs are common to ...
Finnegan, E.Jean, Waterhouse, Peter M., Wang, Ming-Bo, Ming-Bo Wang, E.Jean Finnegan, Waterhouse, Peter, Peter Waterhouse   +6 more
core   +1 more source

Developing a homology-driven gene silencing system in Iris japonica: a versatile tool for comparative functional studies

Ornamental Plant Research
Iris japonica, an evergreen ornamental species known for its beautiful flowers and year-round evergreen foliage, is difficult to genetically manipulate due to the lack of an efficient genetic transformation system.
Cheng Luo, Zhiyan Wu, Lingmei Shao, Jiaping Zhang, Yiping Xia, Danqing Li   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Activation of systemic acquired silencing by localised introduction of DNA [PDF]

, 1999
Background: In plants, post-transcriptional gene silencing results in RNA degradation after transcription. Among tobacco transformants carrying a nitrate reductase (Nia) construct under the control of the cauliflower mosaic virus 35S promoter (35S–Nia2),
Sandrine Balzergue, Jean-Christophe Palauqui, Balzergue, Sandrine, Palauqui, Jean-Christophe   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Simultaneous gene silencing and supressing gene silencing in the same cell [PDF]

, 2013
The present invention relates to genetically modified cells that are capable of optimal transgene expression by co-expressing a silencing suppressor whilst at the same time are also capable of silencing a gene, such as a naturally occurring gene of the ...
Naim, F., Singh, S.P., Wood, C.C.
core