Results 111 to 120 of about 454,191 (307)

Silencing and Un-silencing of Tetracycline-Controlled Genes in Neurons

PLoS ONE, 2007
To identify the underlying reason for the controversial performance of tetracycline (Tet)-controlled regulated gene expression in mammalian neurons, we investigated each of the three components that comprise the Tet inducible systems, namely tetracyclines as inducers, tetracycline-transactivator (tTA) and reverse tTA (rtTA), and tTA-responsive ...
Zhu, Peixin, Aller, M. Isabel, Baron, Udo, Cambridge, Sidney, Bausen, Melanie, Herb, Jan, Sawinski, Juergen, Cetin, Ali, Osten, Pavel, Nelson, Mark L., Kuegler, Sebastian, Seeburg, Peter H., Sprengel, Rolf, Hasan, Mazahir T.   +13 more
openaire   +6 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Knocking down wheat meiotic genes through Virus-induced gene-silencing (VIGS) [PDF]

, 2019
Virus-induced gene-silencing (VIGS) is a reverse genetic technology that can be used to assess gene function in model and crop species. The technique exploits a natural viral defence response in plants, whereby invading viral RNAs are detected, and this ...
Kanyuka, K., Higgins, J. D., Desjardins, S.   +2 more
core  

Gene silencing as an adaptive defence against viruses [PDF]

, 2001
Gene silencing was perceived initially as an unpredictable and inconvenient side effect of introducing transgenes into plants. It now seems that it is the consequence of accidentally triggering the plant's adaptive defence mechanism against viruses and ...
Peter M. Waterhouse, Ming-Bo Wang, Wang, M. B., Lough, T., Waterhouse, P. M., Tony Lough   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Modification of Tobacco rattle virus RNA1 to Serve as a VIGS Vector Reveals That the 29K Movement Protein Is an RNA Silencing Suppressor of the Virus

Molecular Plant-Microbe Interactions, 2013
Tobacco rattle virus (TRV) has a bipartite, positive-sense single-stranded RNA genome and is widely used for virus-induced gene silencing (VIGS) in plants.
Xianbao Deng, Jani Kelloniemi, Tuuli Haikonen, Anssi L. Vuorinen, Paula Elomaa, Teemu H. Teeri, Jari P. T. Valkonen   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

"Plasmodium falciparum" transfection technology for the analysis of "var" gene regulation and knockout investigation [PDF]

, 2007
Malaria is an infectious disease caused by protozoans of the genus Plasmodium, which are injected by the bite of an infected female Anopheles mosquito during a blood meal. Out of the four species that infect humans, P. falciparum is the most important.
Bopp, Selina Elisabeth Ruth
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Plant gene silencing regularized [PDF]

Proceedings of the National Academy of Sciences, 1998
Two surprising and potentially useful phenomena of transgenic plants originated from two distinct lines of research but may converge in underlying mechanism or mechanisms (1–3). Plant transformation technology, the staple of the crop biotechnology industry, overcomes the species barrier and allows introduction into plants of genes from other plant ...
openaire   +2 more sources