Results 81 to 90 of about 3,183,009 (298)
Silencing disease genes in the laboratory and the clinic
, 2011 Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Jonathan K Watts +3 more
core +1 more source
Virus-Induced Gene Silencing of Cell Wall Genes in Flax (Linum usitatissimum)
, 2020 International audiencePlants have developed defense mechanisms against viruses by using an RNA silencing-based process, which has many common features with the endogenous RNA silencing pathway used for regulating the level of transcripts derived from ...
Godfrey Neutelings +5 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Mechanisms underlying epigenetic gene silencing in maize [PDF]
Higher organisms can regulate gene expression through changes in epigenetic marks present on the genome. However, how this regulation takes place in organisms with highly repetitive/complex genomes is not well understood.
Schafer, David Gerald
core
Using interpretable machine learning to understand gene silencing dynamics during X-chromosome inactivation [PDF]
, 2020 To equalize gene dosage between sexes, the long non-coding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals - a process known as X chromosome inactivation (XCI).
Barros de Andrade e Sousa, Lisa +1 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Gene silencing: Fleshing out the bones
, 2001 Genetic studies are revealing the pathway for RNA-mediated gene silencing. Short RNA molecules are the key, giving sequence specificity for RNA degradation and mediating communication within and between cells; these short RNAs are common to ...
Finnegan, E.Jean +5 more
core +1 more source
Ornamental Plant ResearchIris japonica, an evergreen ornamental species known for its beautiful flowers and year-round evergreen foliage, is difficult to genetically manipulate due to the lack of an efficient genetic transformation system.
Cheng Luo +5 more
doaj +1 more source
Cassava geminivirus agroclones for virus-induced gene silencing in cassava leaves and roots
Plant Methods, 2018 Aim We report the construction of a Virus-Induced Gene Silencing (VIGS) vector and an agroinoculation protocol for gene silencing in cassava (Manihot esculenta Crantz) leaves and roots.
Ezequiel Matias Lentz +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source