Results 141 to 150 of about 1,536,047 (259)

Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning. [PDF]

Mol Med, 2023
Founta K, Dafou D, Kanata E, Sklaviadis T, Zanos TP, Gounaris A, Xanthopoulos K.   +6 more
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Double step screening using endogenous marker improves relative gene targeting efficiency in Arabidopsis. [PDF]

Sci Rep
Cheng Y, Zhang L, Ke Y, Dang X, Miki D.
europepmc   +1 more source

A New EBS2b-IBS2b Base Paring (A_-8/T_-8) Improved the Gene-Targeting Efficiency of Thermotargetron in Escherichia coli. [PDF]

Microbiol Spectr, 2023
Cui G, Hua D, Zhao X, Zhou J, Yang Y, Huang T, Wang X, Zhao Y, Zhang T, Liao J, Guan Z, Luo P, Chen Z, Qi X, Hong W.   +14 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Enhancing CRISPR-Cas-based gene targeting in tomato using a dominant-negative ku80. [PDF]

Hortic Res
Vu TV, Nguyen NT, Kim J, Vu MH, Song YJ, Tran MT, Sung YW, Kim JY.   +7 more
europepmc   +1 more source

Cre recombinase microinjection for single-cell tracing and localised gene targeting.

Development, 2023
Sendra M, de Dios Hourcade J, Temiño S, Sarabia AJ, Ocaña OH, Domínguez JN, Torres M.   +6 more
europepmc   +1 more source

Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes. [PDF]

Pharmaceutics, 2022
Petkova AI, Kubajewska I, Vaideanu A, Schätzlein AG, Uchegbu IF.   +4 more
europepmc   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Characterization and regulation of cell cycle-independent noncanonical gene targeting. [PDF]

Nat Commun
Saito S, Adachi N.
europepmc   +1 more source