Results 151 to 160 of about 1,132,364 (264)

R-loops facilitate AAV-mediated nuclease-free gene targeting. [PDF]

Mol Ther
Hu B, Herzog RW, Duan D.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Utilizing shRNA-expressing lentivectors for viral hemorrhagic septicemia virus suppression via NV gene targeting. [PDF]

Front Vet Sci
Pourhoseini Dehkordi N, Saffar B, Mokhtari A, Asadi Samani L, Amini A.   +4 more
europepmc   +1 more source

Enhancing gene editing and gene targeting efficiencies in Arabidopsis thaliana by using an intron-containing version of ttLbCas12a. [PDF]

Plant Biotechnol J, 2023
Schindele P, Merker L, Schreiber T, Prange A, Tissier A, Puchta H.   +5 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues. [PDF]

Sci Rep
Majd-Marani S, Eftekhari A, Elias SG, Beffa R, Alebrahim MT, Mishra AP, Afrouz M.   +6 more
europepmc   +1 more source

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety. [PDF]

Bio Protoc, 2023
Tran NT, Lebedin M, Danner E, Kühn R, Rajewsky K, Chu VT.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Editorial: Prevention of viral diseases by gene targeting. [PDF]

Front Genome Ed
Luo F, Wang Q, Chen S.
europepmc   +1 more source

Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes. [PDF]

Pharmaceutics, 2022
Petkova AI, Kubajewska I, Vaideanu A, Schätzlein AG, Uchegbu IF.   +4 more
europepmc   +1 more source