Results 171 to 180 of about 1,207,125 (312)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development of Modular Geminivirus-Based Vectors for High Cargo Expression and Gene Targeting in Plants. [PDF]

Plant Biotechnol J
Neubauer M, Vollen K, Zhao C, Ascencio-Ibáñez JT, Hanley-Bowdoin L, Stepanova AN, Alonso JM.   +6 more
europepmc   +1 more source

Gene targeting techniques for Huntington's disease. [PDF]

Ageing Res Rev, 2021
Fields E, Vaughan E, Tripu D, Lim I, Shrout K, Conway J, Salib N, Lee Y, Dhamsania A, Jacobsen M, Woo A, Xue H, Cao K.   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

SSA-mediated selection marker gene activation enhances relative gene targeting efficiency in plants. [PDF]

Hortic Res
Kong D, Cheng Y, Ke Y, Dang X, Liu X, Wang C, Huang C, Ye R, Miki D.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Novel Therapies in Advanced Pancreatic Cancer: A Peak Beyond the Realms of Gene Targeting. [PDF]

Cureus
Dave P, Beriwala V, Parikh C, Uddin A, Dayala H, Patel RH, Chirumamilla PC, Winer A.   +7 more
europepmc   +1 more source

Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting. [PDF]

Anim Cells Syst (Seoul), 2022
Jeong YJ, Cho J, Kwak J, Sung YH, Kang BC.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Gene targeting in polymerase theta-deficient Arabidopsis thaliana. [PDF]

Plant J, 2022
van Tol N, van Schendel R, Bos A, van Kregten M, de Pater S, Hooykaas PJJ, Tijsterman M.   +6 more
europepmc   +1 more source