Results 191 to 200 of about 1,734,183 (310)

A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues. [PDF]

Sci Rep
Majd-Marani S, Eftekhari A, Elias SG, Beffa R, Alebrahim MT, Mishra AP, Afrouz M.   +6 more
europepmc   +1 more source

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety. [PDF]

Bio Protoc, 2023
Tran NT, Lebedin M, Danner E, Kühn R, Rajewsky K, Chu VT.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Double step screening using endogenous marker improves relative gene targeting efficiency in Arabidopsis. [PDF]

Sci Rep
Cheng Y, Zhang L, Ke Y, Dang X, Miki D.
europepmc   +1 more source

Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes. [PDF]

Pharmaceutics, 2022
Petkova AI, Kubajewska I, Vaideanu A, Schätzlein AG, Uchegbu IF.   +4 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Editorial: Prevention of viral diseases by gene targeting. [PDF]

Front Genome Ed
Luo F, Wang Q, Chen S.
europepmc   +1 more source

Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis. [PDF]

PeerJ, 2023
Liu T, Zhang B, Gao Y, Zhang X, Tong J, Li Z.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Characterization and regulation of cell cycle-independent noncanonical gene targeting. [PDF]

Nat Commun
Saito S, Adachi N.
europepmc   +1 more source