Results 201 to 210 of about 1,734,183 (310)

Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint. [PDF]

RNA Biol, 2023
Gawlitt S, Liao C, Achmedov T, Beisel CL.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Enhancing CRISPR-Cas-based gene targeting in tomato using a dominant-negative ku80. [PDF]

Hortic Res
Vu TV, Nguyen NT, Kim J, Vu MH, Song YJ, Tran MT, Sung YW, Kim JY.   +7 more
europepmc   +1 more source

Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning. [PDF]

Mol Med, 2023
Founta K, Dafou D, Kanata E, Sklaviadis T, Zanos TP, Gounaris A, Xanthopoulos K.   +6 more
europepmc   +1 more source

Cell division responsive peptides for optimized plasmid DNA delivery : the mitotic window of opportunity? [PDF]

, 2014
De Smedt, Stefaan, Demeester, Jo, Lucas, Bart, Remaut, Katrien, Symens, Nathalie   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cas12a-mediated gene targeting by sequential transformation strategy in Arabidopsis thaliana. [PDF]

BMC Plant Biol
Li J, Wei Q, Cheng Y, Kong D, Kong Z, Ke Y, Dang X, Zhu JK, Shimada H, Miki D.   +9 more
europepmc   +1 more source

Cre recombinase microinjection for single-cell tracing and localised gene targeting.

Development, 2023
Sendra M, de Dios Hourcade J, Temiño S, Sarabia AJ, Ocaña OH, Domínguez JN, Torres M.   +6 more
europepmc   +1 more source

Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies. [PDF]

Int J Mol Sci, 2022
Chamakioti M, Karantzelis N, Taraviras S.   +2 more
europepmc   +1 more source

Gene Targeting and in Vivo Gene Transfer

Cell Transplantation, 1994
openaire   +3 more sources