Precise and heritable gene targeting in rice using a sequential transformation strategy. [PDF]
Cell Rep Methods, 2023 Zhang W +13 more
europepmc +1 more source
Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. [PDF]
, 1994 Shoji Yamanaka +7 more
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. [PDF]
, 1994 Robert J. Bohinski +2 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. [PDF]
Immunol Rev, 2023 Dreismann AK +6 more
europepmc +1 more source
A method for overproduction of a protein of a target gene in Escherichia coli.
, 1988 Tatsurou Shibui +2 more
openalex +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Study of the homologous recombination genetic system to improve genetic transformation of wheat
Czech Journal of Genetics and Plant Breeding, 2005 A. De Bustos, R. Pérez, N. Jouve
doaj +1 more source
Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells. [PDF]
Sci Rep, 2022 Bäckström A +5 more
europepmc +1 more source