Results 201 to 210 of about 708,347 (229)

Gene targeting in hemostasis. plasminogen

Frontiers in Bioscience, 2001
A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice.
openaire   +3 more sources

Gene Targeting

2012
Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
openaire   +2 more sources

Targeting the “species gene ensemble”

Hippocampus, 2002
AbstractThe members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the ‘genetic background’ leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout
openaire   +3 more sources

Target genes of homeodomain proteins

BioEssays, 1999
Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
openaire   +3 more sources

Gene targeting to the retina

Advanced Drug Delivery Reviews, 2001
Yoshikazu Yonemitsu, Taiji Sakamoto, Yasuhiro Ikeda   +2 more
openaire   +3 more sources

Gene Targeting

2009
Yasuko Kamisugi, Andrew C. Cuming
openaire   +1 more source

Targeting cancer metabolism in the era of precision oncology

Nature Reviews Drug Discovery, 2022
Arantxa Gorostiaga, Zachary T Schug, Joseph M Salvino   +2 more
exaly  

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

Angewandte Chemie - International Edition, 2021
Shipeng He, Fei Gao, Guoqiang Dong
exaly  

Tumor‐Associated Immune‐Cell‐Mediated Tumor‐Targeting Mechanism with NIR‐II Fluorescence Imaging

Advanced Materials, 2022
Homan Kang, Shinya Yokomizo, Hyejin Chang   +2 more
exaly  

Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release

Advanced Science, 2021
Shaobo Ruan, Huile Gao
exaly