Results 301 to 310 of about 12,185,719 (426)

Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells [PDF]

, 1991
Jan van Deursen, Robin Lovell‐Badge, Frank Oerlemans, Jan Schepens, Bé Wieringa   +4 more
openalex   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, Volume 19, Issue 5, Page 1532-1545, May 2025.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

An efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum. [PDF]

AMB Express
Ishii M, Yamada T, Ohata S.
europepmc   +1 more source

Generation of Sigmar1 conditional knockout mouse using CRISPR-Cas9 gene targeting. [PDF]

Genesis, 2022
Huang L, Xiao H, Xie X, Hu F, Tang F, Smith SB, Gan L.   +6 more
europepmc   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Recent Progress in Gene-Targeting Therapies for Spinal Muscular Atrophy: Promises and Challenges. [PDF]

Genes (Basel)
Haque US, Yokota T, Yokota T.
europepmc   +1 more source

Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting. [PDF]

PLoS One, 2021
Lassègue B, Kumar S, Mandavilli R, Wang K, Tsai M, Kang DW, Demos C, Hernandes MS, San Martín A, Taylor WR, Jo H, Griendling KK.   +11 more
europepmc   +1 more source

Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.

, 1994
Tsukasa Baba, Sadahiro Azuma, Shin‐ichi Kashiwabara, Yutaka Toyoda   +3 more
openalex   +1 more source

The (6;9) Chromosome Translocation, Associated with a Specific Subtype of Acute Nonlymphocytic Leukemia, Leads to Aberrant Transcription of a Target Gene on 9q34 [PDF]

, 1990
Marieke von Lindern, Annemarie Poustka, Hans Lerach, Gerard C. Grosveld   +3 more
openalex   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source