Results 381 to 390 of about 12,185,719 (426)

Targeted gene regulation and gene ablation

Trends in Endocrinology & Metabolism, 2001
Investigations of the mechanisms involved in appropriate, developmentally regulated tissue-specific gene transcription have laid the foundations for transgenic and gene-therapy technologies directing specific induction or ablation of genes of interest in a tissue-restricted manner.
Sophia Y. Tsai, Francesco J. DeMayo
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Gene targeting in the mouse

BioEssays, 1994
AbstractMice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated.
openaire   +3 more sources

Gene Targeting by Homologous Recombination

, 2014
Gene targeting by homologous recombination involves the exchange of genetic information between genomic and exogenous deoxyribonucleic acid (DNA) molecules via crossover events.
W. A. Reh, K. Vasquez
semanticscholar   +1 more source

Antibodies for targeted gene therapy: extracellular gene targeting and intracellular expression

Advanced Drug Delivery Reviews, 1998
Antibody genes of human origin and human antibodies directed against human proteins have become widely available in recent years. These are valuable reagents for gene therapy applications, in which the use of human proteins and genes allows for increased therapeutic benefit. Engineered human antibodies can be used in gene therapy both as a component of
Wayne A. Marasco, Susan Dana Jones
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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Science, 1994
Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same ...
H. Gu, J. Marth, P. Orban, H. Mossmann, K. Rajewsky   +4 more
semanticscholar   +1 more source

Gene Targeting for Gene Therapy: Prospects

Molecular Genetics and Metabolism, 1999
Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Advances in Targeted Gene Delivery

Current Drug Delivery, 2019
Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g.
Ara Begum, Anjuman, Toth, Istvan, Hussein, Waleed M., Moyle, Peter Michael   +3 more
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Gene targeting of retinoid receptors

Molecular Biotechnology, 1998
Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome.
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Targeting Ochratoxin Biosynthetic Genes

2016
The pathway of ochratoxin A (OTA) biosynthesis has not yet been completely elucidated. Essentially, two kind of genes have been demonstrated to be involved in the biosynthesis of OTA. One of them is the nrps gene encoding a non-ribosomal peptide synthetase (NRPS) which catalyzes the ligation between the isocoumarin group, constituting the polyketide ...
Gallo Antonia, Perrone Giancarlo
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Gene targeting in hemostasis. plasminogen

Frontiers in Bioscience, 2001
A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice.
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