Results 41 to 50 of about 1,824,389 (266)
Scientific Reports, 2023 Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies.
Nadine von Auw +10 more
doaj +1 more source
Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector [PDF]
, 2015 Neointima formation and vascular remodelling through vascular smooth muscle cell migration and proliferation can limit the long term success of coronary interventions, for example in coronary artery bypass grafting (CABG).
Baker, Andrew H. +4 more
core +2 more sources
Gene-level pharmacogenetic analysis on survival outcomes using gene-trait similarity regression [PDF]
Annals of Applied Statistics 2014, Vol. 8, No. 2, 1232-1255, 2014 Gene/pathway-based methods are drawing significant attention due to their usefulness in detecting rare and common variants that affect disease susceptibility. The biological mechanism of drug responses indicates that a gene-based analysis has even greater potential in pharmacogenetics.
arxiv +1 more source
Stem-cell-based gene therapy for HIV infection. [PDF]
, 2013 Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core +2 more sources
Cold Spring Harbor Perspectives in Medicine, 2012 Over 450 million people worldwide suffer from hearing loss, leading to an estimated economic burden of ∼$750 billion. The past decade has seen significant advances in the understanding of the molecular mechanisms that contribute to hearing, and the environmental and genetic factors that can go awry and lead to hearing loss.
Omar Akil, Lawrence R. Lustig
openaire +6 more sources
Challenges in constructing genetic instruments for pharmacologic therapies [PDF]
arXiv, 2020 The genes that encode the targets of most therapies do not have rare variants with large-effect or common variants with moderate effects on the biomarker reflecting the pharmacologic action of the corresponding therapy. Therefore, providing genetic target validation for most therapies is challenging.
arxiv
On dynamic network entropy in cancer [PDF]
Sci Rep. 2012;2:802, 2012 The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level insights into disease mechanisms and ultimately for developing improved therapies.
arxiv +1 more source
Scientific Reports, 2021 A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales +11 more
doaj +1 more source
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]
, 2014 Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W. +30 more
core +3 more sources
EMBO Molecular MedicinePhysiological regulation of transgene expression is a major challenge in gene therapy. Onasemnogene abeparvovec (Zolgensma®) is an approved adeno-associated virus (AAV) vector gene therapy for infants with spinal muscular atrophy (SMA), however, adverse ...
Qing Xie +16 more
doaj +1 more source