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Stable In-Planta Transformation System For Egyptian Sesame (Sesamum indicum L.) cv. Sohag 1
GM Crops & Food, 2023 Sesame (Sesamum indicum L.) is an important oil crop and one of the oldest-known oil crops to humankind. Sesame has excellent nutritional and therapeutic properties; it is rich in important fatty acids, protein, fiber, and vital minerals.
Esraa A. A. Sultan, Mohamed S. Tawfik
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Cells, 2023 Infantile parkinsonism-dystonia due to dopamine transporter deficiency syndrome (DTDS) is an ultrarare childhood movement disorder caused by biallelic loss-of-function mutations in the SLC6A3 gene.
Joanne Ng +3 more
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Immunomodulation in Administration of rAAV: Preclinical and Clinical Adjuvant Pharmacotherapies
Frontiers in Immunology, 2021 Recombinant adeno-associated virus (rAAV) has attracted a significant research focus for delivering genetic therapies to target cells. This non-enveloped virus has been trialed in many clinical-stage therapeutic strategies but important obstacle in ...
Wing Sum Chu, Joanne Ng
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Expression of Alpha Amylase and Osmotin-Like Protein under Drought Stress in Sugar Beet [PDF]
Journal of Agricultural Chemistry and Biotechnology, 2018 Sugar beet is considered as an essential crop to produce sugar, and its common name in plant breeding is Beta vulgaris L. Production of sugar beet is regularly limited by environmental circumstances which result in reduction of photosynthesis rates ...
abo bakr Youssef +3 more
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Frontiers in Immunology, 2020 Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important components of the ...
Natalie Suff +16 more
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Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
EMBO Molecular Medicine, 2021 Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which detaches the ...
Marina Pavlou +16 more
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Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
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Genetic Diversity of Koala Retroviral Envelopes
Viruses, 2015 Genetic diversity, attributable to the low fidelity of reverse transcription, recombination and mutation, is an important feature of infectious retroviruses.
Wenqin Xu +4 more
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Molecular Therapy: Methods & Clinical Development, 2022 Wilson’s disease (WD) is an inherited disorder of copper metabolism associated with mutations in ATP7B gene. We have shown that the administration of an adeno-associated vector (AAV) encoding a mini version of human ATP7B (VTX-801) provides long-term ...
Oihana Murillo +13 more
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Neurobiology of Disease, 2004 γ-Secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin, anterior pharynx defective-1 (Aph-1; A or B), and presenilin enhancer-2 (Pen-2), and is responsible for the cleavage of a number
Sébastien S. Hébert +8 more
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