Results 11 to 20 of about 11,371,695 (398)
Multiple pathways of plasmid DNA transfer in Helicobacter pylori [PDF]
, 2012 Many Helicobacter pylori (Hp) strains carry cryptic plasmids of different size and gene content, the function of which is not well understood. A subgroup of these plasmids (e.g.
Benghezal, Mohammed +5 more
core +7 more sources
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
EMBO Molecular Medicine, 2021 Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which detaches the ...
Marina Pavlou +16 more
doaj +1 more source
Gene transfer in the GI tract and oral cavity [PDF]
, 2000 Gene transfer is important in spreading antibiotic resistance and other traits such as virulence factors. In this review the molecular mechanisms of gene transfer are outlined and the biological consequences of bacterial gene transfer in the GI tract and
Mullany, P
core +1 more source
Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
doaj +1 more source
Current Opinion in Immunology, 1997 DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism
S K, Huang, K Y, Chua, K H, Hsieh
openaire +2 more sources
Perinatal Gene Transfer to the Liver [PDF]
, 2011 The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM +6 more
core +1 more source
Genetic Diversity of Koala Retroviral Envelopes
Viruses, 2015 Genetic diversity, attributable to the low fidelity of reverse transcription, recombination and mutation, is an important feature of infectious retroviruses.
Wenqin Xu +4 more
doaj +1 more source
Neurobiology of Disease, 2004 γ-Secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin, anterior pharynx defective-1 (Aph-1; A or B), and presenilin enhancer-2 (Pen-2), and is responsible for the cleavage of a number
Sébastien S. Hébert +8 more
doaj +1 more source
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
, 2010 Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA +5 more
core +3 more sources
Continual conscious bioluminescent imaging in freely moving somatotransgenic mice
Scientific Reports, 2017 Luciferase bioimaging in living animals is increasingly being applied in many fields of biomedical research. Rodent imaging usually involves anaesthetising the animal during data capture, however, the biological consequences of anaesthesia have been ...
Rajvinder Karda +11 more
doaj +1 more source