Results 261 to 270 of about 5,395,678 (315)
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Tissue Engineering, 1995
The cardiovascular system is a promising site for gene delivery because of its large surface area and direct contact with the blood stream. Gene transfer into vascular cells by adenoviral and retroviral vectors or liposomes has been demonstrated in several cell types and animal models.
A D, Ouellette, K K, Wu, A G, Mikos
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The cardiovascular system is a promising site for gene delivery because of its large surface area and direct contact with the blood stream. Gene transfer into vascular cells by adenoviral and retroviral vectors or liposomes has been demonstrated in several cell types and animal models.
A D, Ouellette, K K, Wu, A G, Mikos
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Current Protocols in Human Genetics, 2001
AbstractThis unit provides a set of protocols for introducing recombinant genes into normal, injured, and atherosclerotic arteries. The protocols include animal preparation, surgical techniques, and delivery systems. Protocols describe gene delivery to normal, injured, and stented porcine iliofemoral arteries, employing a double balloon infusion ...
Levent M, Akyürek +4 more
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AbstractThis unit provides a set of protocols for introducing recombinant genes into normal, injured, and atherosclerotic arteries. The protocols include animal preparation, surgical techniques, and delivery systems. Protocols describe gene delivery to normal, injured, and stented porcine iliofemoral arteries, employing a double balloon infusion ...
Levent M, Akyürek +4 more
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Gene transfer in ophthalmology
Der Ophthalmologe, 1999Research into the molecular and genetic basis of disease is continually expanding. How does the increasing knowledge about the genetic basis of eye diseases contribute to the development of new therapeutic strategies?Gene therapy, here defined as the introduction of genetic material into human cells, offers great opportunities. Gene transfer strategies
M B, Reichel +3 more
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Gene Transfer to the Cerebellum
The Cerebellum, 2010There are several diseases for which gene transfer therapy to the cerebellum might be practicable. In these studies, we used recombinant Tag-deleted SV40-derived vectors (rSV40s) to study gene delivery targeting the cerebellum. These vectors transduce neurons and microglia very effectively in vitro and in vivo, and so we tested them to evaluate gene ...
Jean-Pierre, Louboutin +3 more
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Science, 1987
Until recently, gene transfer in plants was achieved only by sexual hybridization. Now, in addition, plant genetic manipulation, with the use of both recombinant DNA and protoplast fusion technology, is being applied to an increasing range of plants. The soil bacterium Agrobacterium tumefaciens , with its associated
E C, Cocking, M R, Davey
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Until recently, gene transfer in plants was achieved only by sexual hybridization. Now, in addition, plant genetic manipulation, with the use of both recombinant DNA and protoplast fusion technology, is being applied to an increasing range of plants. The soil bacterium Agrobacterium tumefaciens , with its associated
E C, Cocking, M R, Davey
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1987
Publisher Summary Transgenic mice provide a powerful assay system to characterize temporal and spatial patterns of gene expression to analyze the role of specific molecules in complex biological phenomena and alter the physiology of whole animals in defined ways. This chapter reviews the broad areas in which transgenic mice have made or are likely to
G, Scangos, C, Bieberich
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Publisher Summary Transgenic mice provide a powerful assay system to characterize temporal and spatial patterns of gene expression to analyze the role of specific molecules in complex biological phenomena and alter the physiology of whole animals in defined ways. This chapter reviews the broad areas in which transgenic mice have made or are likely to
G, Scangos, C, Bieberich
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Current Cardiology Reports, 2001
Recent improvements in both gene transfer vectors and in vivo gene delivery techniques have facilitated genetic manipulation of myocardial function and enabled targeted therapy of animal models of cardiac disease and, in particular, heart failure.
D C, White, W J, Koch
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Recent improvements in both gene transfer vectors and in vivo gene delivery techniques have facilitated genetic manipulation of myocardial function and enabled targeted therapy of animal models of cardiac disease and, in particular, heart failure.
D C, White, W J, Koch
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Current Opinion in Lipidology, 1997
Vascular gene transfer may be useful for the treatment of several cardiovascular diseases. It can also be used as an experimental tool to test the effects of various genes in a local vascular compartment. Promising therapeutic effects have been obtained in animal models of restenosis with the transfer of vascular endothelial growth factor, nitric oxide
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Vascular gene transfer may be useful for the treatment of several cardiovascular diseases. It can also be used as an experimental tool to test the effects of various genes in a local vascular compartment. Promising therapeutic effects have been obtained in animal models of restenosis with the transfer of vascular endothelial growth factor, nitric oxide
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2009
Membrane electroporation (MEP) uses short high-voltage pulses to render cell membranes transiently porous and therewith permeable to otherwise impermeable substances. This technique was first described, in vitro, by Neumann in 1982. In vivo, this method is restricted to solid tissues accessible to the electrodes used to apply the electric field pulses.
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Membrane electroporation (MEP) uses short high-voltage pulses to render cell membranes transiently porous and therewith permeable to otherwise impermeable substances. This technique was first described, in vitro, by Neumann in 1982. In vivo, this method is restricted to solid tissues accessible to the electrodes used to apply the electric field pulses.
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Gene Co-Inheritance and Gene Transfer
Science, 2007Functional transfer of mitochondrial genes to the nucleus is very common in some taxa but entirely lacking in others. Current evolutionary theories to account for this variation predict that outcrossing, which allows escape from Muller's ratchet and faster spread of beneficial mutations, should favor gene transfer. We find that functional gene transfer
Yaniv, Brandvain +2 more
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