Results 281 to 290 of about 10,802,441 (400)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

A natural mechanism of eukaryotic horizontal gene transfer

Urquhart AS, O'Donnell S, Gluck-Thaler E, Vogan AA.   +3 more
europepmc   +1 more source

Form and Function: The Factors That Influence the Efficacy of Nanomaterials for Gene Transfer to Plants. [PDF]

Molecules
Osmani Z, Kulka M.
europepmc   +1 more source

Microcell-mediated transfer of human DNA repair gene(s) into xeroderma pigmentosum cells.

, 1981
Kanji Ishizaki, Akihiro Shima, Toyozo Sekiguchi, Hiraku Takebe   +3 more
openalex   +2 more sources

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Topological data analysis captures horizontal gene transfer in antimicrobial resistance gene families among clinically relevant bacteria. [PDF]

Front Microbiol
Guerrero-Flores S, Contreras-Peruyero H, Ibarra-Rodríguez JM, Lovaco-Flores JA, Nieto-de la Rosa FS, Fontove-Herrera F, Sélem-Mojica N.   +6 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Efficient gene transfer by pulse parameters for electrochemotherapy of cells <i>in vitro</i> and in muscle and melanoma tumors in mice. [PDF]

Radiol Oncol
Omerzel M, Markelc B, Brezar SK, Sersa G, Cemazar M.   +4 more
europepmc   +1 more source

Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

, 1989
Christopher G. Dowson, A. Hutchison, J.A. Brannigan, Robert C. George, David Hansman, Josefina Liñares, Alexander Tomasz, John Maynard Smith, Brian G. Spratt   +8 more
openalex   +1 more source