Oriental lily hybrids engineered to resist aphid attack [PDF]
, 2009 Establishing in vitro bulb scale cultures of lily cultivars followed by callusing and regeneration after gene transfer was found to be not very successful in our hands, except for ‘Snow Queen’.
Chang, L. +4 more
core +2 more sources
The Routes of Emergence of Life from LUCA during the RNA and Viral World: A Conspectus
Life, 2015 How did life emerge on Earth? The aim of the Network of Researchers on Horizontal Gene Transfer and the Last Universal Cellular Ancestor (NoR HGT & LUCA) is to understand how the genetics of LUCAs were reorganised prior to the advent of the three ...
Sohan Jheeta
doaj +1 more source
Binding Partners of Alzheimer's Disease Proteins: Are They Physiologically Relevant?
Neurobiology of Disease, 2000 Protein–protein interactions are a molecular basis for the structural and functional organization within cells. They are mediated by a growing number of protein modules that bind peptide targets.
Geert Van Gassen +2 more
doaj +1 more source
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]
, 1992 We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G. +36 more
core +1 more source
Journal of Immunology Research, 2015 Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined.
Megha S. Nivsarkar +7 more
doaj +1 more source
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +8 more
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Intratracheal aerosolization of viral vectors to newborn pig airways
BioTechniques, 2020 Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose.
Ashley L Cooney, Patrick L Sinn
doaj +1 more source
Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. [PDF]
, 2020 Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events.
Bhargava, Raag +10 more
core
Systemic Treatment of Fabry Disease Using a Novel AAV9 Vector Expressing α-Galactosidase A
Molecular Therapy: Methods & Clinical Development, 2021 Fabry disease is a rare X-linked disorder affecting α-galactosidase A, a rate-limiting enzyme in lysosomal catabolism of glycosphingolipids. Current treatments present important limitations, such as low half-life and limited distribution, which gene ...
Maria Grazia Biferi +14 more
doaj +1 more source
Gene therapy:the potential applicability of gene transfer technology to the human germline [PDF]
, 2004 The theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans.
Smith, Kevin R.
core +3 more sources