Results 71 to 80 of about 11,371,695 (398)

Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

mBio, 2019
Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro.
Hongping Jin, Yifan Sun, Dongsheng Li, Min-Hsuan Lin, Mary Lor, Lina Rustanti, David Harrich   +6 more
doaj   +1 more source

Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression [PDF]

, 2019
OBJECTIVE: The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes.
Chan, Albert, Eckert, George J., Kirmani, Kashif, Shi, Shuiliang, Trippel, Stephen B., Wang, Congrong   +5 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Adenovirus mediated gene transfer in organotypic brain slices

Neurobiology of Disease, 1995
A replication-defective adenovirus vector carrying the reporter gene encoding β-galactosidase was used to transfect organotypic slices maintained in culture for up to 1 month.
V. Ridoux, J.-J. Robert, M. Perricaudet, J. Mallet, G. Le Gal La Salle   +4 more
doaj   +1 more source

Cotton Biotechnology: An Efficient Gene Transfer Protocol via Agrobacterium tumefaciens for a Greater Transgenic Recovery

Journal of Natural Fibers, 2022
Due to its economic worth, cotton (Gossypium hirsutum L.) is grown in almost 70 countries and provides income for more than 250 million people. Therefore, producing cotton with having some desired characteristics that includes extended biotic and abiotic
Ibrahim Ilker Ozyigit, Ilhan Dogan, Yilmaz Kaya, Kasim Bajrovic, Nermin Gozukirmizi   +4 more
doaj   +1 more source

The infinitely many genes model with horizontal gene transfer

, 2014
The genome of bacterial species is much more flexible than that of eukaryotes. Moreover, the distributed genome hypothesis for bacteria states that the total number of genes present in a bacterial population is greater than the genome of every single ...
Baumdicker, Franz, Pfaffelhuber, Peter
core   +1 more source

Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]

, 1996
We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D., Mislick, Kimberly A.   +1 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide-encoding gene transfer to modulate intracellular protein-protein interactions

Molecular Therapy: Methods & Clinical Development
Peptide drug discovery has great potential, but the cell membrane is a major obstacle when the target is an intracellular protein-protein interaction (PPI). It is difficult to target PPIs with small molecules; indeed, there are no intervention tools that
Toshihiko Taya, Daisuke Kami, Fumiya Teruyama, Satoaki Matoba, Satoshi Gojo   +4 more
doaj   +1 more source

Multidrug Resistant Acinetobacter Isolates Release Resistance Determinants Through Contact-Dependent Killing and Bacteriophage Lysis

Frontiers in Microbiology, 2020
Antimicrobial resistance is an ancient bacterial defense mechanism that has rapidly spread due to the frequent use of antibiotics for disease treatment and livestock growth promotion.
Clay S. Crippen, Michael J. Rothrock Jr., Susan Sanchez, Christine M. Szymanski   +3 more
doaj   +1 more source