Results 61 to 70 of about 621,194 (302)

Gene therapy in the management of oral cancer: Review of the literature [PDF]

, 2008
Gene therapy essentially consists of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Advances over recent decades in the surgical, radiotherapeutic and chemotherapeutic treatment of oral ...
Ayllón Barbellido, Sonia, Bascones Martínez, Antonio, Campo Trapero, Julián, Cano Sánchez, Jorge, Escudero-Castaño, Nayra, Perea García, M.A.   +5 more
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Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sonoporation-mediated gene transfer into adult rat dorsal root ganglion cells

Journal of Biomedical Science, 2010
Background Gene transfer into many cell types has been successfully used to develop alternative and adjunct approaches to conventional medical treatment. However, effective transfection of postmitotic neurons remains a challenge.
Wu Chih-Hsien, Sheen-Chen Shyr-Ming, Cheng Jiin-Tsuey, Yang Chien-Hui, Chen Kuan-Hung, Lin Chung-Ren, Sy Wei-Dih, Chen Yi-Shen   +7 more
doaj   +1 more source

Generation of mutant pigs by lipofection-mediated genome editing in embryos

Scientific Reports, 2021
The specificity and efficiency of CRISPR/Cas9 gene-editing systems are determined by several factors, including the mode of delivery, when applied to mammalian embryos.
Maki Hirata, Manita Wittayarat, Zhao Namula, Quynh Anh Le, Qingyi Lin, Koki Takebayashi, Chommanart Thongkittidilok, Taro Mito, Sayuri Tomonari, Fuminori Tanihara, Takeshige Otoi   +10 more
doaj   +1 more source

Retargeted adenoviruses for radiation-guided gene delivery [PDF]

, 2016
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz, AP Patel, BL Davidson, C Roller, Cancer Genome Atlas Research Network, D E Hallahan, DA Boothman, DA Reardon, DA Spencer, DE Hallahan, DY Dadey, F Tameire, G Bajocchi, H Hsu, H Li, H Yan, HO McCarthy, JJ Mezhir, K Daino, L N Kaliberova, LM Hendershot, M Gonzalez-Gronow, M Hamdi, M Martin, M Westphal, MA Arap, MJ Gray, N Belousova, N Mittereder, R Datta, R Stupp, R Stupp, RJ Passarella, RR Weichselbaum, S A Kaliberov, S Akli, S Mittal, S Parisi, S Takahashi, SA Kaliberov, SC Noureddini, SL Eck, SS Talibi, T Ichikawa, TA Ajith, TC He, Ulasov IV, V Kapoor, VN Krasnykh, WL Blalock, WW Zhang, X Xing, Y Touchefeu, Y Zhang, YL Tsai   +54 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Is biotechnology (more) acceptable when it enables a reduction in phytosanitary treatments? A European comparison of the acceptability of transgenesis and cisgenesis.

PLoS ONE, 2017
Reduced pesticide use is one of the reasons given by Europeans for accepting new genetic engineering techniques. According to the advocates of these techniques, consumers are likely to embrace the application of cisgenesis to apple trees.
Damien Rousselière, Samira Rousselière
doaj   +1 more source

An Overview of the Use of Neural Networks for Data Mining Tasks [PDF]

, 2012
In the recent years the area of data mining has experienced a considerable demand for technologies that extract knowledge from large and complex data sources.
Alberts B, Alpaydin E, Ando T, Blake CL, Bramer MA, Castanheira LG, Han J, Lu H, Mitchell M, Ni X, Quinlan RJ, Rumelhart DE, Shafer JC, Shendure J, Simić D, Stahl F, Steinwart I, Surjandari I, Wei JS, Widrow B, Witten IH, Zaslavsky B, Zhang D   +22 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Addressing the fears of the natural rubber supply chain regarding the dissemination of genetically modified rubber trees [PDF]

, 2011
The development of genetic engineering in Hevea is designed to speed up the breeding process for traits that are essential to the sustainable production of natural rubber.
Montoro, Pascal
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