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The thermodynamics of general anesthesia [PDF]

Biophys. J. 92 (2007) 3159-3165, 2006
It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton
Abelho, Andrew D. Jackson, Boheim, Cantor, Cantor, Cantor, Cantor, Cruzeiro-Hansson, Ebel, Firestone, Firestone, Franks, Franks, Galla, Halsey, Heimburg, Heimburg, Jain, Johnson, Kamaya, Kaminoh, Kaminoh, Katz, Kendig, Kharakoz, Kinnunen, Kobatake, Kreienbühl, Langerman, Lee, Lee, Meyer, Moss, Overton, Papahadjopoulos, Peoples, Punnia-Moorthy, Ritchie, Roth, Silbey, Spyropoulos, Thomas Heimburg, Trudell, Träuble, Träuble, Urban, van de Vossenberg   +46 more
arxiv   +6 more sources

The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes [PDF]

J. Phys. Chem. B 111 (2007) 13858-13866, 2007
In the proximity of melting transitions of artificial and biological membranes fluctuations in enthalpy, area, volume and concentration are enhanced. This results in domain formation, changes of the elastic constants, changes in permeability and slowing down of relaxation processes. In this study we used pressure perturbation calorimetry to investigate
Antonov V. F., Antonov V. F., Blume A., Bovill J. G., Brown D. A., Böckmann R. A., Böttner M., Cannon B., Cantor R. S., Cantor R. S., Cantor R. S., Chapman D., Cruzeiro-Hansson L., Ebel H., Ebel H., Elamrani K., Franks N., Gaus K., Gennis R. B., Genz A., Grabitz P., Gruenewald B., Halstenberg S., Halstenberg S., Heimburg T., Heimburg T., Heimburg T., Heimburg T., Heimburg T., Helms J. B., Hill T. L., Hinderliter A., Hinz H.-J., Holzwarth J. F., Holzwarth J. F., Jackson M. B., Jacobson K., Johnson M. L., Kaufmann K., Kharakoz D. P., Korlach J., Krasowski M., Lee J., Melchior D. L., Melo E. C., Mitaku S., Mountcastle D., Nagle J. F., Onsager L., Onsager L., Papahadjopoulos D., Pollakowski D., Sackmann E., Salinas D. G., Schmidt D., Seeger H., Seeger H. M., Seeger H. M., Simons K., Singer S., Steim J. M., Strehlow U., Tamura K., Thompson T., Trudell J. R., Träuble H., Tsong T. Y., Tsong T. Y., Turnheim K., Ueda I., van Osdol W. W., van Osdol W. W., van Osdol W. W., van Osdol W. W., Vaz W. L., Winter R., Yao H.   +76 more
arxiv   +4 more sources

Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations. [PDF]

Anesthesiology, 2019
General anesthetics have been used to ablate consciousness during surgery for more than 150 yr. Despite significant advances in our understanding of their molecular-level pharmacologic effects, comparatively little is known about how anesthetics alter ...
Voss LJ, García PS, Hentschke H, Banks MI.   +3 more
europepmc   +2 more sources

Regulatory Effect of General Anesthetics on Activity of Potassium Channels. [PDF]

Neurosci Bull, 2018
General anesthesia is an unconscious state induced by anesthetics for surgery. The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades.
Li Y, Xu J, Xu Y, Zhao XY, Liu Y, Wang J, Wang GM, Lv YT, Tang QY, Zhang Z.   +9 more
europepmc   +2 more sources

Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]

Biophysical Journal, 2013
A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
E. Gray, J. Karslake, B. Machta, S. Veatch   +3 more
arxiv   +3 more sources

Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State. [PDF]

Front Neural Circuits, 2018
It has been argued that general anesthetics suppress the level of consciousness, or the contents of consciousness, or both. The distinction between level and content is important because, in addition to clarifying the mechanisms of anesthesia, it may ...
Phillips WA, Bachmann T, Storm JF.
europepmc   +2 more sources

Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness. [PDF]

Front Neural Circuits, 2017
There has been controversy regarding the precise mechanisms of anesthetic-induced unconsciousness, with two salient approaches that have emerged within systems neuroscience.
Mashour GA, Hudetz AG.
europepmc   +2 more sources

Randomized controlled trial of the effect of general anesthetics on postoperative recovery after minimally invasive nephrectomy [PDF]

Korean Journal of Anesthesiology
Background General anesthetic techniques can affect postoperative recovery. We compared the effect of propofol-based total intravenous anesthesia (TIVA) and desflurane anesthesia on postoperative recovery.
Hyun-Kyu Yoon, Somin Joo, Susie Yoon, Jeong-Hwa Seo, Won Ho Kim, Ho-Jin Lee   +5 more
doaj   +2 more sources

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Frontiers in Oncology, 2021
Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Chien-shan Cheng
exaly   +3 more sources

Editorial: Neural circuits underlying general anesthetics mediated consciousness changes [PDF]

Frontiers in Neural Circuits, 2023
Cheng Zhou
doaj   +2 more sources