Results 31 to 40 of about 11,135,694 (289)

Are Local Anesthetics and General Anesthetics Different? [PDF]

Biophysical Journal, 2014
It is widely believed that general and local anesthetics act by different mechanisms. While there is general agreement that the mode of action of general anesthetics is poorly understood, local anesthetics are believed to block voltage-gated sodium channels and thereby affect action potentials in nerves.
Sasse-Middelhoff, Henrike, Zecchi, Karis, Heimburg, Thomas   +2 more
openaire   +1 more source

Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats

Frontiers in Neurology, 2013
General anesthetics are neurotoxic to neonatal rodents and nonhuman primates. Neonatal exposure to general anesthetics has been associated with long-term cognitive deficits in animal models. Some data from humans are consistent with long-term deleterious
Kathy L Murphy, Mark G Baxter
doaj   +1 more source

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Frontiers in Synaptic Neuroscience, 2022
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel, Hugh C. Hemmings Jr., Hugh C. Hemmings Jr.   +2 more
doaj   +1 more source

Neurosteroids and their potential as a safer class of general anesthetics. [PDF]

J Anesth
Neurosteroids (NS) are a class of steroids that are synthesized within the central nervous system (CNS). Various NS can either enhance or inhibit CNS excitability and they play important biological roles in brain development, brain function and as ...
Tateiwa H, Evers AS.
europepmc   +2 more sources

General anesthetic binding mode via hydration with weak affinity and molecular discrimination: General anesthetic dissolution in interfacial water of the common binding site of GABAA receptor

Biophysics and Physicobiology, 2023
The GABAA receptor (GABAAR) is a target channel for the loss of awareness of general anesthesia. General anesthetic (GA) spans a wide range of chemical structures, such as monatomic molecules, barbital acids, phenols, ethers, and alkanes.
Tomoyoshi Seto
doaj   +1 more source

Prevalence Of General Anesthetics In The General Surgery Clinic At The University Clinical Center Of Kosovo [PDF]

Introduction – Anesthesia is a controlled, temporary state of insensitivity or unconsciousness induced for various medical purposes. It involves the use of medications (called anesthetics) to prevent pain during procedures or surgery.Objective – The aim ...
Hoxhaj, Vesa, Mala, Arlind
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles

Frontiers in Neurology, 2012
Exposure to general anesthetics and antiepileptics during critical stages of brain development causes significant neurotoxicity to immature neurons.
Vesna eJevtovic-Todorovic, Annalisa eBoscolo, Victoria eSanchez, Nadia eLunardi   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Alcohol Interactions with Lipid Bilayers

Molecules, 2017
We investigate the structural changes to lipid membrane that ensue from the addition of aliphatic alcohols with various alkyl tail lengths. Small angle neutron diffraction from flat lipid bilayers that are hydrated through water vapor has been employed ...
Tomáš Kondela, Jana Gallová, Thomas Hauß, Jonathan Barnoud, Siewert-J. Marrink, Norbert Kučerka   +5 more
doaj   +1 more source