Results 51 to 60 of about 11,135,694 (289)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs
Frontiers in Veterinary Science, 2022 General anesthesia increases the production of reactive oxygen species (ROS), which can exacerbate or increase oxidative stress and thus affect the prognosis of surgical procedures.
Katerina Tomsič, Alenka Nemec Svete
doaj +1 more source
Prevalence of general anesthetics use in the Clinic of Surgery at the University Clinical Center of Kosovo [PDF]
Introduction - Anesthesia is a state of controlled, temporary loss of sensation or consciousness that is induced for various medical purposes. It refers to the use of medications (called anesthetics) so that we do not feel pain during procedures or ...
Hakaj, Jehona
core +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Volatile general anesthetics enhance desensitization of GABA receptor-Cl^- channel complex [PDF]
Effects of volatile general anesthetics, halothane, isoflurane and enflurane, on γ-aminobutyric acid (GABA)-induced Cl^- current of rat dorsal root ganglion neurons in primary culture were studied by the whole-cell patch-clamp technique. Bath application
Nakahiro, Masanobu +2 more
core +1 more source
Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using Docking [PDF]
, 2012 BACKGROUND: The protein targets for general anesthetics remain unclear. A tool to predict anesthetic binding for potential binding targets is needed.
Liu, Renyu +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk +10 more
wiley +1 more source
General Anesthetic Actions on GABAA Receptors [PDF]
Current Neuropharmacology, 2010 General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor.
Garcia, Paul S +2 more
openaire +2 more sources
Pharmacology of Intravenous Anesthetics
, 2022 Intravenous anesthetics are commonly used in modern anesthesia for induction and maintenance of general anesthesia and for sedation in various clinical settings (e.g., ICU, short procedures, pediatrics). This thesis gives an overview of the mechanism
Wang, Cong-Tian
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source