Results 21 to 30 of about 11,135,694 (289)

The effect of lidocaine on apoptotic neurodegeneration in the developing mouse brain [PDF]

Korean Journal of Anesthesiology, 2014
BackgroundGeneral anesthetics induce neuronal apoptosis in the immature brain. Regional anesthesia using local anesthetics can be an alternative to general anesthesia.
Ji-Hyun Lee, Yong-Hee Park, Hyun-Gul Song, Hee-Pyoung Park, Hee-Soo Kim, Chong-Sung Kim, Jin-Tae Kim   +6 more
doaj   +1 more source

Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration

BMC Anesthesiology, 2021
Background Although general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function remains unclear. We aimed to investigate the effects of general anesthetics on spontaneous respiration in non-
Xuechao Hao, Mengchan Ou, Yu Li, Cheng Zhou   +3 more
doaj   +1 more source

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Frontiers in Oncology, 2021
Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Jiaqiang Wang, Chien-shan Cheng, Chien-shan Cheng, Yan Lu, Shen Sun, Shaoqiang Huang   +5 more
doaj   +1 more source

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus. [PDF]

, 2012
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear.
Dodt Hans-Ulrich, Hans-Ulrich Dodt, Eder, Matthias, Ranft, Andreas, Ludwig von Meyer, Zieglgänsberger Walter, Ranft Andreas, von Meyer, Ludwig, Klaus Becker, Eberhard Kochs, Becker, K., Walter Zieglgänsberger, Kochs Eberhard, Matthias Eder, Kochs, Eberhard, Becker Klaus, Andreas Ranft, von Meyer, L., Dodt, H., Becker, Klaus, Zieglgänsberger, Walter, Eder, M., Eder Matthias, Zieglgänsberger, W., Meyer, Ludwig von, von Meyer Ludwig, Dodt, Hans-Ulrich, Ranft, A., Kochs, E., Becker, K;Eder, M;Ranft, A;von Meyer, L;Zieglgänsberger, W;Kochs, E;Dodt, HU   +29 more
core   +1 more source

General anesthetics in children: neurotoxic or neuroprotective? [PDF]

, 2017
Introduction: general anesthetics are involved in neuroprotection in adults after ischemic events and cognitive impairment, thus, they also may be associated with learning disorders in children exposed to them before three years of age. Objective ...
Araújo de Morais, Sara, Sara Araújo de Morais, Farias Rebouças, Jéssica, Teixeira Batista, Hermes Melo, Bezerra de Menezes Silveira, Gylmara, Jéssica Farias Rebouças, Gylmara Bezerra de Menezes Silveira, Maria de Fátima Vasques Monteiro, Hermes Melo Teixeira Batista, Vasques Monteiro, Maria de Fátima   +9 more
core   +1 more source

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Cell Reports, 2018
Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentameric
Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue   +7 more
doaj   +1 more source

A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

Brain Sciences, 2014
The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain ...
Sunny Chiao, Zhiyi Zuo
doaj   +1 more source

Inhalational versus total intravenous anesthesia in noncardiac surgery: a comparative review of clinical outcomes [PDF]

Korean Journal of Anesthesiology
Inhalational anesthetics have long been the cornerstone of general anesthesia in noncardiac surgery owing to their reliable pharmacokinetics, ease of administration, and cardiopulmonary benefits such as bronchodilation and myocardial preconditioning ...
Ah Ran Oh, Jungchan Park
doaj   +1 more source

Early postoperative recovery in operating room after desflurane anesthesia combined with Bispectral index (BIS) monitoring and warming in lengthy abdominal surgery: a randomized controlled study

BMC Anesthesiology, 2018
Background This study aimed to determine whether the use of desflurane (DES) anesthesia combined with bispectral index (BIS) monitoring and warming is effective in reducing anesthesia-controlled operating room time (ACT) in patients undergoing lengthy ...
Hong Yu, Lu Zhang, Ye Ma, Hai Yu
doaj   +1 more source

Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain

Frontiers in Neurology, 2022
General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community.
Jiaojiao Wang, Jiaojiao Wang, Zhihui Liu
doaj   +1 more source