Results 51 to 60 of about 77,182 (352)

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Frontiers in Veterinary Science, 2022
General anesthesia increases the production of reactive oxygen species (ROS), which can exacerbate or increase oxidative stress and thus affect the prognosis of surgical procedures.
Katerina Tomsič, Alenka Nemec Svete
doaj   +1 more source

Mechanisms of action of general anesthetics

Frontiers in Bioscience, 2014
Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia
Peirong Liu, Shu Diao, Jing Ni, Xiaowei Shi, Wei Xia   +4 more
openaire   +3 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis

iScience, 2023
Summary: The cellular and molecular actions of general anesthetics to induce anesthesia state and also cellular signaling changes for subsequent potential “long term” effects remain largely elusive.
Enqiang Chang, Yangyang Wang, Ruilou Zhu, Lingzhi Wu, Yitian Yang, Shuang Zeng, Ningtao Li, Xiaoguo Ruan, Mingyang Sun, Wei Zhang, Jun Zhou, Mengrong Miao, Hui Zhi, Hailin Zhao, Qian Chen, Qizhe Sun, Emer Chang, Albert Chang, Tingting Zhang, Xinfang He, Kan Liu, Songhua Ma, Weizhong Zhu, Youming Zhang, Luca Magnani, Daqing Ma, Jiaqiang Zhang   +26 more
doaj   +1 more source

The use of tricaine methanesulfonate, clove oil, metomidate, and 2-phenoxyethanol for anesthesia induction in alewives (Alosa pseudoharengus) [PDF]

, 2015
Anesthetics are widely used in routine aquaculture operations to immobilize animals for tagging, spawning, handling, and vaccination. A number of anesthetics are currently available for finfish, but their efficacy and optimal dosage is highly species ...
Watson, Mark Thomas
core   +2 more sources

Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water [PDF]

, 2017
The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport ...
A. G. Becker, ALMROTH B.C., AZAMBUJA C.R., B. Baldisserotto, B. M. Heinzmann, BALDISSEROTTO B., BECKER A.G., BECKER A.G., BENOVIT S.C., BLENAU W., BRADFORD M.M., BUEGE J.A., C. C. Menezes, C. C. Zeppenfeld, C. Toni, COOKE S.J., CUNHA M.A., CUNHA M.A., DUBOIS M., ELLMAN G.L., ELLMAN G.L., GONÇALVES A.F.N., GOYAL A.K., HABIG W.H., HARROWER J.R., HUDETZ A.G., INOUE L.A.K.A., INOUE L.A.K.A., J. Salbego, LEUNG L.S., LINTERN M.C., LOWRY O.H., LÓPEZ M.D., MATÉS J.M., MAZZANTI L., MOMMSEN T.P., PANKHURST N.W., PARODI T.V., ROSS L.G., ROUBACH R., SALBEGO J., SALBEGO J., TONI C., UNGVARI Z., V. L. Loro, VALE T.G., VALE T.G., VILLARES JUNIOR G.A., YAN L.J., YONAR M.E., ZAHL I.H.   +50 more
core   +2 more sources

General Anesthetic Actions on GABAA Receptors [PDF]

Current Neuropharmacology, 2010
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor.
Paul S. García, Scott E Kolesky, Andrew Jenkins   +2 more
openaire   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

Neurotoxicity of General Anesthetics [PDF]

Anesthesiology, 2009
General anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and ...
Misha Perouansky, Hugh C. Hemmings, Bruno Riou   +2 more
openaire   +2 more sources