Results 81 to 90 of about 7,142,009 (388)
General Anesthetics to Treat Major Depressive Disorder: Clinical Relevance and Underlying Mechanisms
Anesthesia and Analgesia, 2018 Major depressive disorder is a frequent and devastating psychological condition with tremendous public health impact. The underlying pathophysiological mechanisms involve abnormal neurotransmission and a relatedly impaired synaptic plasticity.
L. Vutskits
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats
Frontiers in Neurology, 2013 General anesthetics are neurotoxic to neonatal rodents and nonhuman primates. Neonatal exposure to general anesthetics has been associated with long-term cognitive deficits in animal models. Some data from humans are consistent with long-term deleterious
Kathy L Murphy, Mark G Baxter
doaj +1 more source
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia [PDF]
General anesthetics act on neurons to cause overall suppression of neuronal activity in the brain leading to loss of consciousness that renders a patient unarousable to painful stimuli.
10280752 +5 more
core +1 more source
The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
core +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Neurotoxicity of General Anesthetics [PDF]
Anesthesiology, 2009 General anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and ...
Misha Perouansky +2 more
openaire +2 more sources
The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?
Biomolecules, 2023 Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age.
Vesna Jevtovic-Todorovic +1 more
doaj +1 more source
Radical pairs may play a role in microtubule reorganization [PDF]
arXiv, 2021 The exact mechanism behind general anesthesia remains an open question in neuroscience. It has been proposed that anesthetics selectively prevent consciousness and memory via acting on microtubules (MTs). It is known that the magnetic field modulates MT organization. A recent study shows that a radical pair model can explain the isotope effect in xenon-
arxiv