Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Genome‐wide association analyses reveal the genetic basis of combining ability in rice
Summary Combining ability is a measure for selecting elite parents and predicting hybrid performance in plant breeding. However, the genetic basis of combining ability remains unclear and a global view of combining ability from diverse mating designs is ...
Junxiao Chen +9 more
semanticscholar +1 more source
Daya Gabung dan Heterobeltiosis Karakter Pertumbuhan dan Hasil Beberapa Galur Backcross Cabai Merah Toleran CMV pada Kondisi Terinokulasi [PDF]
Information on combining ability and heterosis are desirable to determine the best parents in chili pepper hybrid variety development. To estimate general and specific combining abilities and heterobeltiosis of backcross lines selected for CMV tolerance,
Handajaningsih, D. M. (dan) +2 more
core
Estimation of combining ability for yield and yield component traits in upland rice (Oryza Sativa L.) of Uttarakhand hills [PDF]
Combining ability for grain yield and its component characters in rainfed upland rice (Oryza sativa L.) were studied during Kharif 2014 using half diallel involving ten parents viz., VL Dhan 221, Vivek Dhan 154, VL 30240, VL 7620, VL 30560, VL 8116, VL ...
Aditya, J. P., Bhartiya, Anuradha
core +2 more sources
Novel and unscrutinized immune entities of the zebrafish gut
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Combining ability analysis in Safflower (Carthamus tinctorious L.) [PDF]
Ten parents and their 45 F1 were evaluated for seed yield and its component characters over two environments viz, normal sown (E1) and late sown (E2) conditions.
Gopal Nai, Jogendra Singh*, S. P. Sharma and Chhagan Lal
doaj
Bottle gourd [Lagenaria siceraria (Molina) Standl.] is cultivated for multiple utilities, including as a leafy vegetable, for fresh and dried fruits and seeds. It is an under-researched and -utilized crop, and modern varieties are yet to be developed and
Phumzile Mkhize +2 more
doaj +1 more source
Combining ability studies in restorer lines of sunflower (Helianthus annuus L.) [PDF]
The restorer lines are used to get fertile hybrids in hybrid seed production system of sunflower. Improve-ment of R-lines for fertility and oil content of sunflower is required to get desirable hybrids upon crossing.
Diwan, J. R. +4 more
core +2 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Understanding the combining ability for physiological traits in soybean
Photosynthetic efficiency has become the target of several breeding programs since the positive correlation between photosynthetic rate and yield in soybean suggests that the improvement of photosynthetic efficiency may be a promising target for new ...
L. Teodoro +7 more
semanticscholar +1 more source

