Results 91 to 100 of about 390,567 (307)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Combining ability for yield and yield-associated traits in wheat (Triticum aestivum L.)
Electronic Journal of Plant BreedingThe current breeding effort aims to develop new wheat genotypes with higher genetic potential, thereby contributing to food security. Ten wheat genotypes were crossed in a half-diallel mating design.
Afsar Ahmad1 and Rajesh Kumar Gupta2
doaj +1 more source
Association mapping for general combining ability with yield, plant height and ear height using F1 population in maize. [PDF]
PLoS One, 2021 Zheng Y +8 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Heterosis and combining ability for yield and other agronomic traits in Triticale
Open Agriculture, 2018 The estimation of genetic parameters such as heterosis (Mh), heterobeltiosis (Hh), general combining ability (GCA) and specific combining ability (SCA) allows inferences about the predominant action of the genes, indicates the appropriate selection ...
Ferrari Enzo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Combining Ability for Grain Yield and Popping Expansion in Popcorn (Zea mays everta) Hybrids
Turkish Journal of Agriculture: Food Science and TechnologyThe poor yield and popping quality underscore the need for indigenous germplasm improvement. This study aimed to find parents with high general combining ability (GCA) and specific combining ability (SCA) for yield and popping traits.
Oloruntoba O. Olakojo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Electronic Journal of Plant Breeding, 2020 Eighteen hybrids generated from crossing six lines with three testers were studied along with their parents for combining ability and gene action involved in the expression of characters in barley to identify suitable parents and desirable hybrid ...
Anju Kumari, S.R. Vishwakarma and Yogendra Singh
doaj +1 more source