Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Combining ability for yield and yield-associated traits in wheat (Triticum aestivum L.)
The current breeding effort aims to develop new wheat genotypes with higher genetic potential, thereby contributing to food security. Ten wheat genotypes were crossed in a half-diallel mating design.
Afsar Ahmad1 and Rajesh Kumar Gupta2
doaj +1 more source
Combining ability analysis for seed yield and component traits in Indian mustard [Brassica juncea (L.) Czern & Coss.] [PDF]
Combining ability of eight quantitative traits was studied in 12 lines, 4 testers and 48 F1’s in Line x Tester mating design to know the inheritance pattern of yield attributes of Indian mustard [Brassica juncea (L.) Czern & Coss].
Gideon J. Synrem*, N. R. Rangare, Anil K. Choudhari, Sujeet Kumar and Ibadaiahun Myrthong
doaj
Frequency of heterotic hybrids in relation to general combining ability of parents in sweet corn. [PDF]
Madhunapantula VP +5 more
europepmc +1 more source
Multimodal Observation and Interpretation of Subjects Engaged in Problem Solving [PDF]
In this paper we present the first results of a pilot experiment in the capture and interpretation of multimodal signals of human experts engaged in solving challenging chess problems.
Balzarini, Raffaella +3 more
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Identifying quantitative trait loci for the general combining ability of yield-relevant traits in maize. [PDF]
Liu X +7 more
europepmc +1 more source
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Combining Ability for Grain Yield and Popping Expansion in Popcorn (Zea mays everta) Hybrids
The poor yield and popping quality underscore the need for indigenous germplasm improvement. This study aimed to find parents with high general combining ability (GCA) and specific combining ability (SCA) for yield and popping traits.
Oloruntoba O. Olakojo +3 more
doaj +1 more source
Association mapping for general combining ability with yield, plant height and ear height using F1 population in maize. [PDF]
Zheng Y +8 more
europepmc +1 more source

