Results 131 to 140 of about 2,473,923 (366)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Elucidating the genetic potential of hybrids derived from elite maize (Zea mays L.) inbreds for economic traits under North-Western Himalayan condition

Electronic Journal of Plant Breeding
This study was conducted to evaluate the combining ability of newly acquired maize inbred lines over the environments. Twenty-eight crosses developed by crossing eight elite inbreds in a half-diallel mating design were evaluated during kharif, 2019 for ...
Gaurav Sharma*, Uttam Chandel, Sawan Kumar, Satish Kumar Guleria and Nimit Kumar
doaj   +1 more source

Combining ability studies for yield and yield components trait in hybrid rice (Oryza sativa L.) [PDF]

Electronic Journal of Plant Breeding, 2012
Fifty two hybrids were generated from crossing four CMS lines and thirteen restorer lines in line x tester design. Crosses along with parents were evaluated for yield and yield component traits during rabi, 2011 at RARS, Jagtial, Andhra Pradesh ...
P.V. Padmavathi, P.V. Satyanarayana , Lal Ahamed M.,Y. Ashoka Rani and V. Srinivasa Rao
doaj  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Combining ability analysis for seed yield and component traits in Indian mustard [Brassica juncea (L.) Czern & Coss.] [PDF]

Electronic Journal of Plant Breeding, 2015
Combining ability of eight quantitative traits was studied in 12 lines, 4 testers and 48 F1’s in Line x Tester mating design to know the inheritance pattern of yield attributes of Indian mustard [Brassica juncea (L.) Czern & Coss].
Gideon J. Synrem*, N. R. Rangare, Anil K. Choudhari, Sujeet Kumar and Ibadaiahun Myrthong
doaj  

Association mapping for general combining ability with yield, plant height and ear height using F1 population in maize. [PDF]

PLoS One, 2021
Zheng Y, Han X, Zhao Y, Zhu L, Huang Y, Jia X, Zhang Z, Chen J, Guo J.   +8 more
europepmc   +1 more source

Determination of General and Specific Combining Ability of Five Upland Cotton Cultivars

Journal of Agricultural Science, 2016
<p>The present investigation was aimed to determine the general combining ability of the parental lines and specific combining ability of the hybrids respectively and also heterotic effect of F₁ hybrids for some agro-economical traits in upland cotton. Five parent genotypes viz.
Habib R. Lakho, Shabana Memon, Ayaz A. Soomro, Muhammad Rashid   +3 more
openaire   +2 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Heterosis and combining ability for yield and other agronomic traits in Triticale

Open Agriculture, 2018
The estimation of genetic parameters such as heterosis (Mh), heterobeltiosis (Hh), general combining ability (GCA) and specific combining ability (SCA) allows inferences about the predominant action of the genes, indicates the appropriate selection ...
Ferrari Enzo, Picca Aurora, Domínguez Rodolfo, Paccapelo Héctor   +3 more
doaj   +1 more source