Results 51 to 60 of about 7,136,763 (359)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Cogent Education, 2016 This essay seeks to contribute to growing discussion concerning the need for more intentional inclusion of habits of mind in curriculum development, particularly in undergraduate general education, and to fuel an examination of the “dialectical ...
Jeffrey W. Murray
doaj +1 more source
Framing the concept design literacy for a general public
FORMakademisk, 2021 Educating the general public to be design literate can be a catalyst for both environmental protection and degradation, human aid and human-made disasters depending on how the scope of design is framed – and how ‘design literacy’ is defined.
Eva Lutnæs
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Challenges of workforce pre-professional training for high-tech sectors of the economy in the system of additional education [PDF]
Известия Саратовского университета. Новая серия: Серия Философия. Психология. ПедагогикаIntroduction. The article reveals pre-professional training in secondary schools, which is a complex and multifaceted process aimed at developing students’ professional knowledge, skills and abilities necessary to make an appropriate choice of ...
Kosyrev, Vasiliy P., Gribanov, Igor N.
doaj +1 more source
Effects of a Collaborative Planning and Consultation Framework to Increase Participation of Students with Severe Disabilities in General Education Classes [PDF]
, 2021 Emily M. Kuntz, Erik W. Carter
openalex +1 more source
A Model General Education Science Course Involving Humanities and Sciences, Education, and Medical School Collaboration [PDF]
, 2002 This article described an innovative general education biology course for non-science majors, BIOL 102-Science of Heredity (SOH), stressing active student learning and collaboration [1]. The course has three components. The lecture is taught by J.
Chinnici, J. P.
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liberal Arts Education for a Global Society [PDF]
, 2000 Looks at trends in general and liberal education approaches, and explores the most effective ways to address new reforms for revitalizing liberal arts ...
Carol M. Barker
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