Results 61 to 70 of about 7,283,680 (307)
Liberal And General Studies In Further Education: Voices From The ‘Chalk Face’ [PDF]
, 2014 This paper presents initial findings from research investigating an important but largely neglected facet of the history of Further Education (FE) – the Liberal Studies and General Studies (LS/GS) movement.
Hopkins, Mike +4 more
core +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Who cares about polar regions? Results from a survey of U.S. public opinion [PDF]
, 2008 What do members of the general public know about polar regions, and how much do they care? Who knows or cares? This paper explores data from the General Social Survey (GSS), which in 2006 questioned a representative sample of more than 1800 U.S.
Hamilton, Lawrence C.
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Vietnam Journal of Education, 2021 Over the past several years, various stakeholders have continued to express concerns about the quality of U.S. higher education. Under the accountability and transparency pressures, institutions must provide evidence of student learning, especially the ...
Nhung Thi Tuyet Pham
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Education (Penalty Notices) (England) (Amendment) Regulations 2013 [PDF]
, 2013 Enabling power: Education Act 1996, ss. 444B (1) (2) (4), 569 and Education and Inspections Act 2006, ss. 106 (1) (2) (4), 181. Issued: 04.04.2013. Made: 26.03.2012. Laid: 04.04.2013. Coming into force: 01.09.2013. Effect: S.I.
core
Can We Really Prevent Suicide? [PDF]
, 2012 Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and
A Fagiolini +111 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source