Results 61 to 70 of about 7,046,045 (313)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Literacy education in China within an Inclusive Education context

Per Linguam : A Journal of Language Learning, 2016
To realise educational equality and construct a harmonious society, many scholars have valued and promoted inclusive education in China. More and more scholarly works are being devoted to this topic, forming three main types of studies: basic theories ...
Zhou, Quan , Yang, Jiong
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sustainability: Teaching an Interdisciplinary Threshold Concept through Traditional Lecture and Active Learning

Canadian Journal for the Scholarship of Teaching and Learning, 2015
One of the difficulties in teaching global sustainability in the introductory political science classes is the different emphases placed on this concept and the absence of the consensus on where the overall balance between environmental protection ...
Ekaterina M. Levintova, Daniel W. Mueller   +1 more
doaj  

DEVELOPING A COMPUTER-BASED SYSTEM FOR TESTING AND ASSESSING LEARNERS‘ ABILITY: A CASE STUDY IN GENERAL EDUCATION

Tạp chí Khoa học
The purpose of the study is to propose a computer-based system of testing and assessing learners’ ability for high school students according to the structure of the high school graduation exam format from 2025 of the Vietnam Ministry of Education and ...
Nguyen Phuoc Hai, Trinh Thi Kim Binh
doaj   +1 more source

End-of-Life Care Education as Blended Learning Approach for General Practitioners: a Scoping Review [PDF]

, 2023
Shrikant Atreya, Naveen Salins
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

More Than Numbers: The Relationship Between Belonging and Engagement in an Introductory Statistics Course

Journal of Postsecondary Student Success
More college students from diverse backgrounds and disciplines are enrolling in introductory statistics courses. In these courses, active learning, collaborative projects, and relatable content can help to support student learning, belonging, and ...
Catherine Pressimone Beckowski, Benjamin M. Torsney   +1 more
doaj   +1 more source

MODEL METHODS OF UPBRINGING OF PUPILS IN THE LEARNING PROCESS OF BIOLOGY AND ECOLOGY

Вестник Северо-Кавказского федерального университета, 2022
One of the priorities of school education is the upbringing ofpupils. Educational subject's biology and ecology solve this problem by their own means. The problem of upbringing of pupils faced the methodology of teaching biology and ecology at all times.
A. Semenov
doaj  

A formation of secular school education in the Tatar settlements of Mordovia (1910s – early 1940s)

Известия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2022
Background. Researches are interested in the educational policy of the USSR so far, especially in the context of a multinational state. In this article, the formation of a secular school is shown by the example of the Tatars of Mordovia, whose history ...
A.N. Zankina
doaj   +1 more source