Results 111 to 120 of about 1,452,737 (303)
Parameter sensitivity in nonlinear transient thermal problems
Computer Assisted Methods in Engineering and Science, 2023 A general problem of parameter sensitivity of non-linear transient thermal systems is considered. The non-linear sensitivity path is followed by a weighted residual method employing the continuum description.
Michał Kleiber, Andrzej Slużalec
doaj
Continuous optimal designs for generalised linear models under model uncertainty [PDF]
We propose a general design selection criterion for experiments where a generalised linear model describes the response. The criterion allows for several competing aims, such as parameter estimation and model discrimination, and also for uncertainty in ...
Woods, David C., Lewis, Susan M.
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A General Maximum Principle for Discrete Fractional Stochastic Control System of Mean-Field Type
Discrete Dynamics in Nature and SocietyIn this paper, we investigate a general maximum principle for discrete fractional stochastic difference system of mean-field type. The admissible control domain is nonconvex.
Zheng Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Convergence results for implicit–explicit general linear methods
Applied Numerical Mathematics, 2020 This paper studies fixed-step convergence of implicit-explicit general linear methods. We focus on a subclass of schemes that is internally consistent, has high stage order, and favorable stability properties. Classical, index-1 differential algebraic equation, and singular perturbation convergence analyses results are given.
openaire +3 more sources
Optimum non linear binary image restoration through linear grey-scale operations [PDF]
, 2003 Non-linear image processing operators give excellent results in a number of image processing tasks such as restoration and object recognition. However they are frequently excluded from use in solutions because the system designer does not wish to ...
Marshall, S.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MCMC Methods for Multi-Response Generalized Linear Mixed Models: The MCMCglmm R Package [PDF]
Generalized linear mixed models provide a flexible framework for modeling a range of data, although with non-Gaussian response variables the likelihood cannot be obtained in closed form.
Jarrod D. Hadfield
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source