Results 101 to 110 of about 4,726,480 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Case for Using the General Linear Model as a Unifying Conceptual Framework for Teaching Statistics and Psychometric Theory

Journal of Methods and Measurement in the Social Sciences, 2015
The present paper argues for teaching statistics and psychometric theory using the GLM as a unifying conceptual framework. This helps students understand what analyses have in common, and also provides a firm grounding for understanding that more general
Bruce Thompson
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

One missing value problem in Latin square design of any order: Exact analysis of variance

Cogent Engineering, 2017
This research proposes a simplified exact approach based on the general linear model for solving the K × K Latin square design (LSD) with one replicate and one missing value, given the lack of ready-made mathematical formulas for the sub-variance.
Kittiwat Sirikasemsuk, Kanogkan Leerojanaprapa   +1 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Predicting the Aqueductal Cerebrospinal Fluid Pulse: A Statistical Approach

Applied Sciences, 2019
The cerebrospinal fluid (CSF) pulse in the Aqueduct of Sylvius (aCSF pulse) is often used to evaluate structural changes in the brain. Here we present a novel application of the general linear model (GLM) to predict the motion of the aCSF pulse.
Clive B Beggs, Simon J Shepherd, Pietro Cecconi, Maria Marcella Lagana   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Postharvest Disease Control Experiments: Challenges on Statistical Methodologies

Horticulturae
In postharvest disease (PHD) control experiments, treatments with the same observed values for all their replicates are frequently present, which leads to one or more treatments with zero observed variance—this type of data are referred to as data with ...
Aline de Holanda Nunes Maia, Adriane Maria da Silva, Itala Suzana Oliveira Silva, Daniel Terao   +3 more
doaj   +1 more source

The GridCAT: A Toolbox for Automated Analysis of Human Grid Cell Codes in fMRI

Frontiers in Neuroinformatics, 2017
Human functional magnetic resonance imaging (fMRI) studies examining the putative firing of grid cells (i.e., the grid code) suggest that this cellular mechanism supports not only spatial navigation, but also more abstract cognitive processes.
Matthias Stangl, Jonathan Shine, Thomas Wolbers, Thomas Wolbers   +3 more
doaj   +1 more source