Results 111 to 120 of about 2,182,908 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Graham Whitaker, A Bibliographical Guide to Classical Studies. I. General. History of Literature. Literature : Accius-Aristophanes. II. Literature : Aristotle-Fulgentius

, 1999
Raepsaet-Charlier Marie-Thérèse. Graham Whitaker, A Bibliographical Guide to Classical Studies. I. General. History of Literature. Literature : Accius-Aristophanes. II. Literature : Aristotle-Fulgentius. In: L'antiquité classique, Tome 68, 1999.
Raepsaet-Charlier, Marie-Thérèse
core  

Unlocking insights: general practice staff perspectives on sharing general practice data for research – a scoping review

BMC Primary Care
Background General practice data holds significant potential for secondary use in research, offering insights into healthcare delivery, disease patterns, and informing policy development.
Heidi Green, Belinda Fabrianesi, Lucy Carolan, Justin Beilby, Allison Clarke, Tracey Laba, Annette Braunack-Mayer   +6 more
doaj   +1 more source

Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis

BMJ Open
Objectives To summarise and synthesise existing literature on the implementation of decarbonisation actions in general practice, to outline the actions being implemented, factors influencing decarbonisation, identify evidence gaps and questions for ...
Jeremy Dale, Helen Atherton, Ana Raquel Nunes, Abi Eccles, Rachel Spencer, Helen Twohig, Florence Karaba, Olivia Geddes, Frederik Dahlmann, Michael Gregg, Abi Bickerton   +10 more
doaj   +1 more source

Understanding Pharmacist Communication and Medication Errors: A Systematic Literature Review

Asia Pacific Journal of Health Management, 2017
Objective: To better understand the inter-professional clinical communication between pharmacists, other health professionals and medication errors.
Maryam Sassoli, Gary Day
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tudor Vianu, un comparatist atras de antichitate [PDF]

Revista de Istorie și Teorie Literară, 2012
Tudor Vianu’s studies of world literature and comparative literature – some of which are synthetic, the others, analytic, some devoted to constructing an outline of the general evolution of literature, the others seeking a more in-depth approach to ...
Alexandra Ciocârlie
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Art of Searching: How to Find Terrorism Literature in the Digital Age

Perspectives on Terrorism, 2013
This guide provides an overview on information retrieval techniques for locating high-quality literature on terrorism and counter-terrorism. Starting from general considerations on conducting a literature search – taking into account the specifics ...
Judith Tinnes
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source