Results 81 to 90 of about 2,072,556 (257)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Bibliometric Analysis of Political Science Research on a Global Scale

open access: yesAkademik İncelemeler Dergisi
This research aims to contribute to a macro-level understanding of the intellectual foundations of the field of political science by examining it in depth through bibliometric analysis and discovering the epistemological insights hidden in it, as well as
Emre Aydilek
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dicţionarul general al literaturii române – enciclopedie a literaturii și culturii naționale [PDF]

open access: yesRevista de Istorie și Teorie Literară, 2019
The most comprehensive, representative and imposing lexicographic work of the Romanian literary history and criticism, the General Dictionary of Romanian Literature is a real encyclopedia of our national literature and culture.
Laurențiu Hanganu
doaj  

Literature Study on the Contribution of General Practitioners in Health Promotion and Prevention Efforts

open access: yesNusantara Sehat: Jurnal Kesehatan Indonesia
ABSTRACT This study aims to explore and synthesize the contributions of general practitioners (GPs) in promotive and preventive healthcare, emphasizing their role in strengthening primary health systems and community well-being. Using a qualitative descriptive approach through literature study, data were collected from scientific journals, books, and ...
null Putri Raudhatul Jannah   +1 more
openaire   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Unlocking insights: general practice staff perspectives on sharing general practice data for research – a scoping review

open access: yesBMC Primary Care
Background General practice data holds significant potential for secondary use in research, offering insights into healthcare delivery, disease patterns, and informing policy development.
Heidi Green   +6 more
doaj   +1 more source

Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis

open access: yesBMJ Open
Objectives To summarise and synthesise existing literature on the implementation of decarbonisation actions in general practice, to outline the actions being implemented, factors influencing decarbonisation, identify evidence gaps and questions for ...
Jeremy Dale   +10 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

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