Results 81 to 90 of about 8,081,518 (357)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Dismantling general practice [PDF]
British Journal of General Practice, 2007 Twenty years ago general practice in the UK was frequently and justifiably described as the jewel in the crown of the NHS.1 GPs led primary health care teams which provided comprehensive, continuous, coordinated, and personal care for registered patient populations, and exercised a benign gate-keeping role by regulating patients' access to more ...
openaire +2 more sources
Dental Dam Utilization by Dentists in an Intramural Faculty Practice [PDF]
, 2019 Objectives: From casual observation of our colleagues, only a few individuals use the dental dam for operative procedures in their faculty practice. The purpose of this study was to obtain faculty perceptions of the dental dam, quantify its utilization ...
Carrico, Caroline K., Imbery, Terence A.
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Teaching general practice [PDF]
British Journal of General Practice, 2019 Andrew Blythe’s recent editorial on teaching general practice reminds us of the opportunities to teach diagnostic reasoning, the management of uncertainty, and therapeutics, which appear under-taught in many schools.1,2 There is also an opportunity here for a patient safety focus in consulting, in terms of discussing diagnostic reasoning, …
openaire +2 more sources
Battered women presenting in general practice [PDF]
, 1983 The problems of battered women have recently been highlighted. They consult doctors, who can be an important source of help. We examined their initial presenting complaint to general practitioners.
Hopayian, Kevork
core
How do general practitioners conceptualise advance care planning in their practice? : a qualitative study [PDF]
, 2016 Objectives : To explore how GPs conceptualise advance care planning (ACP), based on their experiences with ACP in their practice. Methods : Five focus groups were held with 36 GPs. Discussions were analysed using a constant comparative method. Results :
Beernaert, Kim +5 more
core +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
BMC Health Services Research, 2019 Background At the end of life, about 85–90% of patients can be treated within primary palliative care (PC) provided by general practitioners (GPs). In Germany, there is no structured approach for the provision of PC by GPs including a systematic as well ...
Kambiz Afshar +7 more
doaj +1 more source
Entering general practice [PDF]
British Journal of General Practice, 2008 Congratulations on publishing Daniel Furmedge's telling short paper.1 Full marks for his insight and interpretation. He reminded me of my first Claire Wand Fund Prize on ‘Postgraduate education …
openaire +2 more sources